The Role of Macrolide Antibiotics in Increasing Cardiovascular Risk

• Published in: Journal of the American College of Cardiology Vol. 66; no. 20; pp. 2173 - 2184
• Main Authors: Cheng, Yun-Jiu, Nie, Xiao-Ying, Chen, Xu-Miao, Lin, Xiao-Xiong, Tang, Kai, Zeng, Wu-Tao, Mei, Wei-Yi, Liu, Li-Juan, Long, Ming, Yao, Feng-Juan, Liu, Jun, Liao, Xin-Xue, Du, Zhi-Min, Dong, Yu-Gang, Ma, Hong, Xiao, Hai-Peng, Wu, Su-Hua
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.11.2015; Elsevier Limited
• Subjects: Anti-Bacterial Agents - adverse effects; Antibiotics; Bacterial infections; Cardiac arrhythmia; Cardiology; Cardiovascular; Cardiovascular disease; Cause of Death; Confidence intervals; coronary heart disease; Death, Sudden, Cardiac - epidemiology; Death, Sudden, Cardiac - etiology; Estimates; Female; Health risk assessment; Heart attacks; Humans; Macrolides - adverse effects; Male; Mortality; Population; Quality; Risk Factors; roxithromycin; Studies; sudden cardiac death; Tachycardia, Ventricular - epidemiology; Tachycardia, Ventricular - etiology; ventricular tachyarrhythmia; ventricular tachyarrhythmia; RR; RCT; VTA; CV; OR; roxithromycin; SCD; CI; coronary heart disease; sudden cardiac death; CHD; odds ratio; cardiovascular; relative risk; randomized controlled trial; ventricular tachyarrhythmias; confidence interval

Large cohort studies provide conflicting evidence regarding the potential for oral macrolide antibiotics to increase the risk of serious cardiac events. This study performed a meta-analysis to examine the link between macrolides and risk of sudden cardiac death (SCD) or ventricular tachyarrhythmias...