Long-term in vivo glucose monitoring using fluorescent hydrogel fibers
The use of fluorescence-based sensors holds great promise for continuous glucose monitoring (CGM) in vivo, allowing wireless transdermal transmission and long-lasting functionality in vivo. The ability to monitor glucose concentrations in vivo over the long term enables the sensors to be implanted a...
Saved in:
Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 33; pp. 13399 - 13403 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
National Academy of Sciences
16.08.2011
National Acad Sciences |
Series | From the Cover |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The use of fluorescence-based sensors holds great promise for continuous glucose monitoring (CGM) in vivo, allowing wireless transdermal transmission and long-lasting functionality in vivo. The ability to monitor glucose concentrations in vivo over the long term enables the sensors to be implanted and replaced less often, thereby bringing CGM closer to practical implementation. However, the full potential of long-term in vivo glucose monitoring has yet to be realized because current fluorescence-based sensors cannot remain at an implantation site and respond to blood glucose concentrations over an extended period. Here, we present a long-term in vivo glucose monitoring method using glucose-responsive fluorescent hydrogel fibers. We fabricated glucose-responsive fluorescent hydrogels in a fibrous structure because this structure enables the sensors to remain at the implantation site for a long period. Moreover, these fibers allow easy control of the amount of fluorescent sensors implanted, simply by cutting the fibers to the desired length, and facilitate sensor removal from the implantation site after use. We found that the polyethylene glycol (PEG)-bonded polyacrylamide (PAM) hydrogel fibers reduced inflammation compared with PAM hydrogel fibers, transdermally glowed, and continuously responded to blood glucose concentration changes for up to 140 days, showing their potential application for long-term in vivo continuous glucose monitoring. |
---|---|
AbstractList | The use of fluorescence-based sensors holds great promise for continuous glucose monitoring (CGM) in vivo, allowing wireless transdermal transmission and long-lasting functionality in vivo. The ability to monitor glucose concentrations in vivo over the long term enables the sensors to be implanted and replaced less often, thereby bringing CGM closer to practical implementation. However, the full potential of long-term in vivo glucose monitoring has yet to be realized because current fluorescence-based sensors cannot remain at an implantation site and respond to blood glucose concentrations over an extended period. Here, we present a long-term in vivo glucose monitoring method using glucose-responsive fluorescent hydrogel fibers. We fabricated glucose-responsive fluorescent hydrogels in a fibrous structure because this structure enables the sensors to remain at the implantation site for a long period. Moreover, these fibers allow easy control of the amount of fluorescent sensors implanted, simply by cutting the fibers to the desired length, and facilitate sensor removal from the implantation site after use. We found that the polyethylene glycol (PEG)-bonded polyacrylamide (PAM) hydrogel fibers reduced inflammation compared with PAM hydrogel fibers, transdermally glowed, and continuously responded to blood glucose concentration changes for up to 140 days, showing their potential application for long-term in vivo continuous glucose monitoring. The use of fluorescence-based sensors holds great promise for continuous glucose monitoring (CGM) in vivo, allowing wireless transdermal transmission and long-lasting functionality in vivo. The ability to monitor glucose concentrations in vivo over the long term enables the sensors to be implanted and replaced less often, thereby bringing CGM closer to practical implementation. However, the full potential of long-term in vivo glucose monitoring has yet to be realized because current fluorescence-based sensors cannot remain at an implantation site and respond to blood glucose concentrations over an extended period. Here, we present a long-term in vivo glucose monitoring method using glucose-responsive fluorescent hydrogel fibers. We fabricated glucose-responsive fluorescent hydrogels in a fibrous structure because this structure enables the sensors to remain at the implantation site for a long period. Moreover, these fibers allow easy control of the amount of fluorescent sensors implanted, simply by cutting the fibers to the desired length, and facilitate sensor removal from the implantation site after use. We found that the polyethylene glycol (PEG)-bonded polyacrylamide (PAM) hydrogel fibers reduced inflammation compared with PAM hydrogel fibers, transdermally glowed, and continuously responded to blood glucose concentration changes for up to 140 days, showing their potential application for long-term in vivo continuous glucose monitoring. The use of fluorescence-based sensors holds great promise for continuous glucose monitoring (CGM) in vivo, allowing wireless transdermal transmission and long-lasting functionality in vivo. The ability to monitor glucose concentrations in vivo over the long term enables the sensors to be implanted and replaced less often, thereby bringing CGM closer to practical implementation. However, the full potential of long-term in vivo glucose monitoring has yet to be realized because current fluorescence-based sensors cannot remain at an implantation site and respond to blood glucose concentrations over an extended period. Here, we present a long-term in vivo glucose monitoring method using glucose-responsive fluorescent hydrogel fibers. We fabricated glucose-responsive fluorescent hydrogels in a fibrous structure because this structure enables the sensors to remain at the implantation site for a long period. Moreover, these fibers allow easy control of the amount of fluorescent sensors implanted, simply by cutting the fibers to the desired length, and facilitate sensor removal from the implantation site after use. We found that the polyethylene glycol (PEG)-bonded polyacrylamide (PAM) hydrogel fibers reduced inflammation compared with PAM hydrogel fibers, transdermally glowed, and continuously responded to blood glucose concentration changes for up to 140 days, showing their potential application for long-term in vivo continuous glucose monitoring. [PUBLICATION ABSTRACT] |
Author | Shibata, Hideaki Takeuchi, Shoji Okitsu, Teru Kawanishi, Tetsuro Heo, Yun Jung |
Author_xml | – sequence: 1 fullname: Heo, Yun Jung – sequence: 2 fullname: Shibata, Hideaki – sequence: 3 fullname: Okitsu, Teru – sequence: 4 fullname: Kawanishi, Tetsuro – sequence: 5 fullname: Takeuchi, Shoji |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21808049$$D View this record in MEDLINE/PubMed |
BookMark | eNpdkUFv1DAQhS3Uim4LZ05AxIVT2nFsx_alEqooVFqph9Kz5SR26lViL3ayUv89Drt0gYt9eN88vZl3jk588AahdxguMXBytfU6XWIMVDKKQbxCKwwSlzWVcIJWABUvBa3oGTpPaQMAkgl4jc4qLEDkoRW6XQffl5OJY-F8sXO7UPTD3IZkijF4N4XofF_MaXntMIdoUmv8VDw9dzH0Ziisa0xMb9Cp1UMybw__BXq8_frj5nu5vv92d_NlXbaM1VPZmqbl3IKwtW5yLtzJSlvLO2mktIJ2lBBKGlJjRmvGTC1Zw2thK26FxISQC3S9993OzWi6JUrUg9pGN-r4rIJ26l_FuyfVh50imAlMWTb4fDCI4eds0qRGlzcaBu1NmJMS-VwccLWQn_4jN2GOPm_3G5Kyrhfoag-1MaQUjX2JgkEtDamlIXVsKE98-HuDF_5PJRkoDsAyebQTihCVbyAX5P0e2aRc0NGCSy4rDFn_uNetDkr30SX1-FABpgBYAuEV-QUaVKwN |
CitedBy_id | crossref_primary_10_1007_s42765_020_00057_5 crossref_primary_10_3389_fbioe_2020_596370 crossref_primary_10_1002_adma_201201232 crossref_primary_10_1007_s13320_021_0622_9 crossref_primary_10_1002_advs_202203943 crossref_primary_10_1039_D0QM01140A crossref_primary_10_1007_s42114_017_0009_y crossref_primary_10_1080_09205063_2018_1475942 crossref_primary_10_3390_bios3040400 crossref_primary_10_1002_asia_201600797 crossref_primary_10_1039_C9SC02033K crossref_primary_10_1016_j_cis_2020_102301 crossref_primary_10_1039_C5CC08633G crossref_primary_10_3390_s19173771 crossref_primary_10_1002_admi_201600692 crossref_primary_10_1016_j_biotechadv_2019_05_004 crossref_primary_10_1016_j_snb_2011_12_024 crossref_primary_10_1002_adpr_202100371 crossref_primary_10_1021_acsami_8b04091 crossref_primary_10_1002_lpor_202100171 crossref_primary_10_1016_j_gce_2022_07_001 crossref_primary_10_1073_pnas_1505405112 crossref_primary_10_1002_hlca_201600311 crossref_primary_10_1016_j_dyepig_2023_111362 crossref_primary_10_3390_s19194333 crossref_primary_10_1098_rsfs_2013_0014 crossref_primary_10_1016_j_bios_2023_115571 crossref_primary_10_1002_adfm_201706635 crossref_primary_10_1039_C5SM01487E crossref_primary_10_2139_ssrn_4016286 crossref_primary_10_1007_s13206_021_00014_3 crossref_primary_10_1016_j_molliq_2023_121910 crossref_primary_10_1021_acs_chemmater_2c03550 crossref_primary_10_1016_j_addr_2021_01_011 crossref_primary_10_1016_j_nantod_2019_100828 crossref_primary_10_3390_ani12213042 crossref_primary_10_1016_j_cis_2023_102920 crossref_primary_10_1002_adhm_201200167 crossref_primary_10_1021_acsami_0c03903 crossref_primary_10_1016_j_snb_2024_136277 crossref_primary_10_1039_C8NJ06229C crossref_primary_10_1039_C9QM00127A crossref_primary_10_1002_marc_201400630 crossref_primary_10_1177_193229681200600602 crossref_primary_10_1016_j_diabres_2012_11_027 crossref_primary_10_1038_srep19370 crossref_primary_10_1371_journal_pone_0186548 crossref_primary_10_3390_jcm11092408 crossref_primary_10_1002_adma_201606380 crossref_primary_10_1002_admt_201800201 crossref_primary_10_1002_adom_201900057 crossref_primary_10_1080_00032719_2024_2310624 crossref_primary_10_1002_adhm_201500553 crossref_primary_10_1039_C5RA19285D crossref_primary_10_1002_adfm_202004327 crossref_primary_10_3390_bios10070079 crossref_primary_10_3762_bjoc_12_42 crossref_primary_10_3934_matersci_2023054 crossref_primary_10_1039_D2TB00968D crossref_primary_10_1016_j_bioactmat_2024_03_031 crossref_primary_10_1016_j_sna_2022_113574 crossref_primary_10_1021_acs_analchem_0c04223 crossref_primary_10_1021_acs_chemrev_1c00044 crossref_primary_10_1039_C8MH01130C crossref_primary_10_1021_acsami_2c00713 crossref_primary_10_1016_j_snb_2013_05_028 crossref_primary_10_1021_acsami_0c13688 crossref_primary_10_9746_sicetr_59_529 crossref_primary_10_1021_acsnano_8b02188 crossref_primary_10_1071_CH13365 crossref_primary_10_1016_j_eurpolymj_2017_06_008 crossref_primary_10_1021_acsmacrolett_0c00621 crossref_primary_10_3390_s21144829 crossref_primary_10_3724_SP_J_1105_2013_13018 crossref_primary_10_1039_c3cs60031a crossref_primary_10_1002_adhm_202101238 crossref_primary_10_1021_acs_biomac_6b01715 crossref_primary_10_1016_j_jphotochem_2023_114743 crossref_primary_10_1021_acsapm_1c01504 crossref_primary_10_3390_molecules27031002 crossref_primary_10_1002_btm2_10604 crossref_primary_10_1088_2631_6331_ab0c80 crossref_primary_10_1016_j_ccr_2023_215194 crossref_primary_10_1149_1945_7111_ac6980 crossref_primary_10_1049_el_2015_0612 crossref_primary_10_1088_1748_605X_abfd11 crossref_primary_10_1016_j_giant_2023_100195 crossref_primary_10_1021_ac501678q crossref_primary_10_1021_acsbiomaterials_6b00403 crossref_primary_10_1109_LAWP_2019_2955176 crossref_primary_10_1021_acsami_5b11493 crossref_primary_10_1021_acs_analchem_2c02600 crossref_primary_10_1039_C4TB00905C crossref_primary_10_1021_cr300387j crossref_primary_10_1541_ieejsmas_132_437 crossref_primary_10_3390_bios11120472 crossref_primary_10_1002_adma_201300818 crossref_primary_10_1016_j_optmat_2015_05_051 crossref_primary_10_1126_sciadv_adh1765 crossref_primary_10_1016_j_snb_2021_131067 crossref_primary_10_1016_j_mattod_2019_12_026 crossref_primary_10_1002_adhm_202001019 crossref_primary_10_1016_j_biomaterials_2013_09_031 crossref_primary_10_1016_j_ijpharm_2018_02_022 crossref_primary_10_1007_s13726_023_01158_9 crossref_primary_10_1016_j_snb_2019_01_163 crossref_primary_10_1039_D0NR07478K crossref_primary_10_1039_C6RA11239K crossref_primary_10_1039_C8RA04503H crossref_primary_10_1109_ACCESS_2021_3098777 crossref_primary_10_3389_fbioe_2018_00047 crossref_primary_10_1039_C5NR08866F crossref_primary_10_1007_s12010_015_1800_2 crossref_primary_10_1016_j_isci_2020_101243 crossref_primary_10_1039_C8PY00515J crossref_primary_10_1039_D2PY00965J crossref_primary_10_1016_j_bios_2014_08_012 crossref_primary_10_1021_ac400575u crossref_primary_10_3390_photonics9020086 crossref_primary_10_1093_nsr_nwaa209 crossref_primary_10_3390_app9102158 crossref_primary_10_1177_08839115241253260 crossref_primary_10_1109_MDAT_2016_2560137 crossref_primary_10_1021_acssensors_1c00844 crossref_primary_10_1016_j_jlumin_2022_119202 crossref_primary_10_1021_acsbiomaterials_0c01547 crossref_primary_10_1021_acs_chemmater_8b05183 crossref_primary_10_1007_s10439_012_0510_y crossref_primary_10_1021_am4049354 crossref_primary_10_1002_marc_201200136 crossref_primary_10_3390_chemosensors10070251 crossref_primary_10_1021_acsbiomaterials_6b00048 crossref_primary_10_1039_D1PY01505B crossref_primary_10_1002_adfm_202104488 crossref_primary_10_1126_science_aaf3627 crossref_primary_10_1016_j_bios_2024_116542 crossref_primary_10_1515_epoly_2019_0022 crossref_primary_10_1007_s10404_017_1926_3 crossref_primary_10_1021_acs_chemrev_2c00192 crossref_primary_10_1177_193229681300700108 crossref_primary_10_1177_193229681300700109 crossref_primary_10_3390_s19051028 crossref_primary_10_1063_1_5122780 crossref_primary_10_1177_193229681300700104 crossref_primary_10_1016_j_smaim_2022_08_003 crossref_primary_10_3390_s21248464 crossref_primary_10_1016_j_eurpolymj_2022_111164 crossref_primary_10_1109_JSEN_2019_2949056 crossref_primary_10_3390_app12062782 crossref_primary_10_34133_adi_0046 crossref_primary_10_1039_D2SD00036A crossref_primary_10_1515_nanoph_2021_0360 crossref_primary_10_1177_1932296815590439 crossref_primary_10_1002_adfm_202407926 crossref_primary_10_1002_adhm_202001286 crossref_primary_10_1016_j_trechm_2020_02_009 crossref_primary_10_1016_j_bios_2021_113054 crossref_primary_10_1364_BOE_5_003859 crossref_primary_10_1007_s41061_020_00322_6 crossref_primary_10_1039_c3cs60148j crossref_primary_10_1039_c2cc17503g crossref_primary_10_1007_s10853_019_03505_9 crossref_primary_10_1038_s41467_022_35440_w crossref_primary_10_1039_C4CC09861G crossref_primary_10_4028_www_scientific_net_MSF_944_543 crossref_primary_10_1021_cr500562m crossref_primary_10_1002_adma201300818 crossref_primary_10_1002_anie_201904416 crossref_primary_10_1039_C9LC00242A crossref_primary_10_1039_C7PY01883E crossref_primary_10_1002_jbm_a_36534 crossref_primary_10_1021_acssensors_0c00718 crossref_primary_10_1016_j_bios_2019_111547 crossref_primary_10_1039_C5TB00326A crossref_primary_10_1002_cplu_201700156 crossref_primary_10_1016_j_ijbiomac_2022_12_148 crossref_primary_10_1016_j_snb_2016_03_146 crossref_primary_10_1002_adfm_202105645 crossref_primary_10_1021_acssensors_0c02566 crossref_primary_10_1021_acsapm_2c01681 crossref_primary_10_1142_S1793292022300067 crossref_primary_10_1177_19322968211070614 crossref_primary_10_1016_j_bios_2020_112004 crossref_primary_10_1021_acs_analchem_1c04730 crossref_primary_10_1016_j_progpolymsci_2024_101847 crossref_primary_10_1016_j_jbiosc_2013_12_024 crossref_primary_10_1039_C4AN01775G crossref_primary_10_1039_C7TB03332J crossref_primary_10_1002_adma_202005930 crossref_primary_10_1007_s10965_017_1188_5 crossref_primary_10_1002_adfm_202213485 crossref_primary_10_1016_j_snb_2017_12_085 crossref_primary_10_1016_j_bios_2019_05_002 crossref_primary_10_1002_adfm_201902906 crossref_primary_10_1002_adfm_202309795 crossref_primary_10_1371_journal_pone_0165839 crossref_primary_10_1002_adfm_201202258 crossref_primary_10_1021_acsabm_2c00664 crossref_primary_10_1039_C4CC01429D crossref_primary_10_1002_aisy_202300482 crossref_primary_10_1021_ac402688k crossref_primary_10_1016_j_bioactmat_2018_05_006 crossref_primary_10_1016_j_jmat_2020_02_002 crossref_primary_10_1016_j_talanta_2023_125248 crossref_primary_10_1007_s00216_015_9152_x crossref_primary_10_1021_acs_nanolett_6b03848 crossref_primary_10_1002_admi_201801233 crossref_primary_10_1021_acsmacrolett_8b00291 crossref_primary_10_1007_s10971_024_06366_0 crossref_primary_10_1088_1361_6528_aa6564 crossref_primary_10_54097_hset_v2i_589 crossref_primary_10_1038_s41528_021_00122_y crossref_primary_10_1016_j_microc_2023_109241 crossref_primary_10_1002_ange_201904416 crossref_primary_10_1039_C5RA19172F crossref_primary_10_1002_adhm_202303546 crossref_primary_10_1021_acssensors_9b02180 crossref_primary_10_1007_s10965_016_0986_5 crossref_primary_10_1016_j_bios_2021_113895 crossref_primary_10_1021_acssensors_2c00821 crossref_primary_10_1039_c2lc40439g crossref_primary_10_3788_LOP231395 crossref_primary_10_1007_s42114_023_00653_0 crossref_primary_10_1021_acs_chemrev_5b00300 crossref_primary_10_1021_acsnano_6b02386 crossref_primary_10_1016_j_bios_2020_112261 |
Cites_doi | 10.1016/j.biomaterials.2004.07.069 10.1073/pnas.86.14.5605 10.1021/cr068123a 10.1056/NEJM200007063430107 10.1002/(SICI)1097-4636(19990305)44:3<298::AID-JBM8>3.0.CO;2-N 10.1016/j.smim.2007.11.004 10.1111/j.1365-2133.1991.tb14165.x 10.1021/ja00140a013 10.1146/annurev.ms.26.080196.002053 10.1016/j.canlet.2004.10.029 10.1023/B:JOFL.0000039338.16715.48 10.1038/280408a0 10.1039/c39940000477 10.1021/ac990060r 10.1016/0956-5663(92)87013-F 10.1016/0927-7765(93)01114-7 10.1016/j.aca.2005.05.080 10.1038/374345a0 10.1016/0142-9612(92)90159-L 10.1007/128_2007_110 10.1073/pnas.1006911107 10.1177/193229680800200610 10.2337/diacare.25.2.347 10.1006/jcis.1998.5513 |
ContentType | Journal Article |
Copyright | copyright © 1993–2008 National Academy of Sciences of the United States of America Copyright National Academy of Sciences Aug 16, 2011 |
Copyright_xml | – notice: copyright © 1993–2008 National Academy of Sciences of the United States of America – notice: Copyright National Academy of Sciences Aug 16, 2011 |
DBID | FBQ CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QG 7QL 7QP 7QR 7SN 7SS 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 M7N P64 RC3 7X8 5PM |
DOI | 10.1073/pnas.1104954108 |
DatabaseName | AGRIS Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database Nucleic Acids Abstracts Ecology Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management Entomology Abstracts Genetics Abstracts Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Chemoreception Abstracts Immunology Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts MEDLINE - Academic |
DatabaseTitleList | MEDLINE Virology and AIDS Abstracts CrossRef |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Sciences (General) |
EISSN | 1091-6490 |
EndPage | 13403 |
ExternalDocumentID | 2429467511 10_1073_pnas_1104954108 21808049 108_33_13399 27979210 US201400190372 |
Genre | Research Support, Non-U.S. Gov't Journal Article Feature |
GroupedDBID | --- -DZ -~X .55 .GJ 0R~ 123 29P 2AX 2FS 2WC 3O- 4.4 53G 5RE 5VS 692 6TJ 79B 85S AACGO AAFWJ AANCE AAYJJ ABBHK ABOCM ABPLY ABPPZ ABPTK ABTLG ABZEH ACGOD ACIWK ACKIV ACNCT ACPRK ADULT ADZLD AENEX AEUPB AEXZC AFDAS AFFNX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS ASUFR AS~ BKOMP CS3 D0L DCCCD DIK DNJUQ DOOOF DU5 DWIUU E3Z EBS EJD F20 F5P FBQ FRP GX1 HGD HH5 HQ3 HTVGU HYE JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JSODD JST KQ8 L7B LU7 MVM N9A NEJ NHB N~3 O9- OK1 P-O PNE PQQKQ R.V RHF RHI RNA RNS RPM RXW SA0 SJN TAE TN5 UKR VOH VQA W8F WH7 WHG WOQ WOW X7M XFK XSW Y6R YBH YKV YSK ZA5 ZCA ZCG ~02 ~KM ABXSQ AQVQM - 02 0R 1AW 55 AAPBV ABFLS ADACO AJYGW DZ H13 KM PQEST X XHC ADACV CGR CUY CVF ECM EIF IPSME NPM AAYXX CITATION 7QG 7QL 7QP 7QR 7SN 7SS 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 M7N P64 RC3 7X8 ADQXQ 5PM |
ID | FETCH-LOGICAL-c556t-cebc77f08f6ab4241d92aff7d9e99f84d43343b36154655e695b768f27f891333 |
IEDL.DBID | RPM |
ISSN | 0027-8424 |
IngestDate | Tue Sep 17 21:24:30 EDT 2024 Fri Aug 16 04:41:20 EDT 2024 Thu Oct 10 17:23:39 EDT 2024 Fri Aug 23 01:10:27 EDT 2024 Sat Sep 28 07:48:57 EDT 2024 Wed Nov 11 00:29:38 EST 2020 Fri Feb 02 07:04:34 EST 2024 Wed Dec 27 19:17:10 EST 2023 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 33 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c556t-cebc77f08f6ab4241d92aff7d9e99f84d43343b36154655e695b768f27f891333 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: Y.J.H. and S.T. designed research; Y.J.H., H.S., and T.O. performed research; Y.J.H., H.S., T.O., T.K., and S.T. analyzed data; and Y.J.H., H.S., T.O., T.K., and S.T. wrote the paper. Edited by Nicholas J. Turro, Columbia University, New York, NY, and approved July 7, 2011 (received for review March 30, 2011) |
OpenAccessLink | https://www.pnas.org/doi/pdf/10.1073/pnas.1104954108 |
PMID | 21808049 |
PQID | 884299665 |
PQPubID | 42026 |
PageCount | 5 |
ParticipantIDs | jstor_primary_27979210 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3158145 fao_agris_US201400190372 pubmed_primary_21808049 crossref_primary_10_1073_pnas_1104954108 proquest_miscellaneous_884270125 proquest_journals_884299665 pnas_primary_108_33_13399 |
ProviderPackageCode | RNA PNE |
PublicationCentury | 2000 |
PublicationDate | 2011-08-16 |
PublicationDateYYYYMMDD | 2011-08-16 |
PublicationDate_xml | – month: 08 year: 2011 text: 2011-08-16 day: 16 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: Washington |
PublicationSeriesTitle | From the Cover |
PublicationTitle | Proceedings of the National Academy of Sciences - PNAS |
PublicationTitleAlternate | Proc Natl Acad Sci U S A |
PublicationYear | 2011 |
Publisher | National Academy of Sciences National Acad Sciences |
Publisher_xml | – name: National Academy of Sciences – name: National Acad Sciences |
References | 25147429 - Colloids Surf B Biointerfaces. 1994 Sep 30;3(1-2):49-62 19885290 - J Diabetes Sci Technol. 2008 Nov;2(6):1003-15 8416751 - Cancer Res. 1993 Jan 1;53(1):53-60 1954120 - Br J Dermatol. 1991 Oct;125(4):325-9 20921374 - Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17894-8 11815508 - Diabetes Care. 2002 Feb;25(2):347-52 10882768 - N Engl J Med. 2000 Jul 6;343(1):37-49 17723330 - Anal Chim Acta. 2006 Jan 18;556(1):46-57 15603824 - Biomaterials. 2005 Jun;26(16):3285-97 2748607 - Proc Natl Acad Sci U S A. 1989 Jul;86(14):5605-9 1633214 - Biomaterials. 1992;13(7):411-6 10397932 - J Biomed Mater Res. 1999 Mar 5;44(3):298-307 18154363 - Chem Rev. 2008 Feb;108(2):814-25 460415 - Nature. 1979 Aug 2;280(5721):408-10 18162407 - Semin Immunol. 2008 Apr;20(2):86-100 15896454 - Cancer Lett. 2005 Jun 8;223(2):203-9 10450158 - Anal Chem. 1999 Aug 1;71(15):3126-32 15617258 - J Fluoresc. 2004 Sep;14(5):499-512 Gruijl FR (e_1_3_3_24_2) 1993; 53 e_1_3_3_17_2 e_1_3_3_16_2 e_1_3_3_19_2 e_1_3_3_18_2 e_1_3_3_13_2 e_1_3_3_12_2 e_1_3_3_15_2 e_1_3_3_14_2 e_1_3_3_11_2 e_1_3_3_10_2 e_1_3_3_6_2 e_1_3_3_5_2 e_1_3_3_8_2 e_1_3_3_7_2 e_1_3_3_9_2 e_1_3_3_23_2 e_1_3_3_25_2 e_1_3_3_2_2 e_1_3_3_20_2 e_1_3_3_1_2 e_1_3_3_4_2 e_1_3_3_22_2 e_1_3_3_3_2 e_1_3_3_21_2 |
References_xml | – ident: e_1_3_3_22_2 doi: 10.1016/j.biomaterials.2004.07.069 – ident: e_1_3_3_23_2 doi: 10.1073/pnas.86.14.5605 – ident: e_1_3_3_2_2 doi: 10.1021/cr068123a – ident: e_1_3_3_16_2 doi: 10.1056/NEJM200007063430107 – ident: e_1_3_3_20_2 doi: 10.1002/(SICI)1097-4636(19990305)44:3<298::AID-JBM8>3.0.CO;2-N – ident: e_1_3_3_17_2 doi: 10.1016/j.smim.2007.11.004 – ident: e_1_3_3_12_2 doi: 10.1111/j.1365-2133.1991.tb14165.x – ident: e_1_3_3_8_2 doi: 10.1021/ja00140a013 – ident: e_1_3_3_18_2 doi: 10.1146/annurev.ms.26.080196.002053 – ident: e_1_3_3_13_2 doi: 10.1016/j.canlet.2004.10.029 – ident: e_1_3_3_4_2 doi: 10.1023/B:JOFL.0000039338.16715.48 – ident: e_1_3_3_21_2 doi: 10.1038/280408a0 – ident: e_1_3_3_6_2 doi: 10.1039/c39940000477 – ident: e_1_3_3_9_2 doi: 10.1021/ac990060r – ident: e_1_3_3_1_2 doi: 10.1016/0956-5663(92)87013-F – ident: e_1_3_3_19_2 doi: 10.1016/0927-7765(93)01114-7 – ident: e_1_3_3_3_2 doi: 10.1016/j.aca.2005.05.080 – ident: e_1_3_3_5_2 doi: 10.1038/374345a0 – ident: e_1_3_3_25_2 doi: 10.1016/0142-9612(92)90159-L – ident: e_1_3_3_7_2 doi: 10.1007/128_2007_110 – ident: e_1_3_3_10_2 doi: 10.1073/pnas.1006911107 – ident: e_1_3_3_15_2 doi: 10.1177/193229680800200610 – ident: e_1_3_3_14_2 doi: 10.2337/diacare.25.2.347 – ident: e_1_3_3_11_2 doi: 10.1006/jcis.1998.5513 – volume: 53 start-page: 53 year: 1993 ident: e_1_3_3_24_2 article-title: Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice publication-title: Cancer Res contributor: fullname: Gruijl FR |
SSID | ssj0009580 |
Score | 2.544926 |
Snippet | The use of fluorescence-based sensors holds great promise for continuous glucose monitoring (CGM) in vivo, allowing wireless transdermal transmission and... |
SourceID | pubmedcentral proquest crossref pubmed pnas jstor fao |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 13399 |
SubjectTerms | Acrylic Resins Animals Biocompatibility Blood Blood glucose Blood Glucose - analysis Fluorescence Gastroscopy Glucose Glycols hydrocolloids Hydrogels Hydrogels - chemistry Inflammation Inflammation - prevention & control Male Mice monitoring Monitoring, Physiologic - methods Monomers Physical Sciences polyacrylamide polyethylene glycol Polyethylene Glycols Prostheses and Implants Sensors Swelling Transplants & implants |
Title | Long-term in vivo glucose monitoring using fluorescent hydrogel fibers |
URI | https://www.jstor.org/stable/27979210 http://www.pnas.org/content/108/33/13399.abstract https://www.ncbi.nlm.nih.gov/pubmed/21808049 https://www.proquest.com/docview/884299665 https://search.proquest.com/docview/884270125 https://pubmed.ncbi.nlm.nih.gov/PMC3158145 |
Volume | 108 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB51e-KCKFAaCsgHDuWQbuO3j6hiVSGKkGCl3qw4sbcr7SarfVTi3-Nxkt0WceLsR6yxxzPj-eYLwEfM_TDJQx6EwTRjUeXahZB7UdZIAOeEwmrk2-_yZsq_3om7IxBDLUwC7VduftkslpfN_D5hK1fLajzgxMY_bq9ZIXTBxXgEI8XYEKLvmXZ1V3dC4_XLKR_4fBQbr5pyg7j3GBTw4konImDkVUQizUdWaRTKdoAnIudpHPUv__NvGOUjuzR5Ac97h5J87hZ-Ake-eQknvcpuyEXPK_3pFUy-tc0sx6uYzBvyMH9oSQ9YJ8uk2fjERxAIPyNhsWvXHdMTuf9dr9uZX5CA6JLNa5hOvvy6vsn73yjklRBym1feVUqFKx1k6aJAitrQMgRVG29M0DzuCePMsejbIJmal0a4GIQEqgLmMBk7heOmbfwZEGpKKSl1PsaFXElVslrUcaioC69cHTK4GMRoVx1bhk1ZbsUsitEehJ_BWRSzLWfxLrPTnxQjPaxrZ4pmcJpkv5-CKqNMjE0zyNIsh6m1ZczGNRqTwfmwQ7ZXw43VGs2tlCIDsm-N-oNJkbLx7a7roqKVjl3edNt5-Gx_ODJQTzZ63wGpuZ-2xBObKLr7E_r2v0eew7Ph9bqQ7-B4u97599H92boP6bj_ARgg_5s |
link.rule.ids | 230,315,733,786,790,891,27955,27956,53825,53827 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lc9MwEN5pywEuQIFS0xZ04FAOTmrJkqxjp0MmQNJhhobpTWPZUpohsTN5dAZ-PVo_krbTC5z1sOVdrXa1334G-Ii5HyZiFzquMM0YZWFinAstT3MkgDNcYjXy8FL0R_HXa369A7ythalA-5mZdIrprFNMbips5XyWdVucWPf78IJFPIli3t2FJ36_Ut4G6Ruu3aSuPKHeAMc0bhl9JOvOi3SJyHcfFsTRWVJRASOzIlJp3jmXdl1atgBFZD31ox7zQB8CKe-cTL0X8LNdUw1I-dVZr0wn-_OA7vGfF_0Snje-Kjmvm_dhxxavYL-xBkty2lBWf3oNvUFZjEO08mRSkNvJbUkaLDyZVUYDbw8JYuzHxE3X5aImkSI3v_NFObZT4hC4snwDo97nq4t-2PyhIcw4F6swsyaT0p0lTqTGf-koVzR1TubKKuWS2Iubxcww7zYhT5sVihsf3zgqHaZHGTuAvaIs7CEQqlIhKDXWh5yxFDJlOc_9UJ5HVprcBXDaykfPayIOXSXQJdMoH72VagCHXn46HXszqUc_KAaRWDLPJA3goBLqZgoqlVQ-7A0gqGbZTp1oxrR_R6UCOGpFr5sdvtRJgie5EDwAsmn1WxPzLWlhy3XdRXoHwHd5W-vJ9rGN1gUg72nQpgOyft9v8XpRsX83evDuv0d-gKf9q-FAD75cfjuCZ-0leSSOYW-1WNsT72WtzPtqT_0FTLEhmw |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB7RIiEuhQKlaSn4wKEcsmns2I6PqHRVoK0qwUoVFytO7O2K3WS1j0rw6_HksbutOPWcsRNnxuMZz-fPAB-x9sNE4kLHFZYZ4zxMjXOh5VmBBHCGSzyNfHklzgfJtxt-s3HVVw3az82oV44nvXJ0W2Mrp5M86nBi0fXlKYt5Gic8mhYu2oKnfs5S2SXqK77dtDl9Qr0TTmjSsfpIFk3LbI7od58aJPFJWtMBI7si0mlurE1bLqs6kCIyn_pW_4tCH4IpN1an_gv41Y2rAaX87i0Xppf_fUD5-KiBv4SdNmYlnxuRXXhiy1ew23qFOTluqas_vYb-RVUOQ_T2ZFSSu9FdRVpMPJnUzgN3EQli7YfEjZfVrCGTIrd_ilk1tGPiEMAyfwOD_tnP0_OwvakhzDkXizC3JpfSnaROZMb_7bhQNHNOFsoq5dLEq50lzDAfPiFfmxWKG5_nOCodlkkZ24PtsirtPhCqMiEoNdannokUMmMFL3xTXsRWmsIFcNzpSE8bQg5dF9Il06gjvdZsAPtehzobenepBz8oJpN4dJ5JGsBerdhVF1QqqXz6G0BQ97LuOtWMaf-NSgVw2KlftzN9rtMUV3QheABk9dRPUay7ZKWtlo2I9IGAF3nb2Mr6ta3lBSDvWdFKANm_7z_xtlGzgLe2cPDolh_g2fWXvr74evX9EJ53e-WxeAfbi9nSHvlga2He19PqH3zuJBs |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Long-term+in+vivo+glucose+monitoring+using+fluorescent+hydrogel+fibers&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Heo%2C+Yun+Jung&rft.au=Shibata%2C+Hideaki&rft.au=Okitsu%2C+Teru&rft.au=Kawanishi%2C+Tetsuro&rft.date=2011-08-16&rft.eissn=1091-6490&rft.volume=108&rft.issue=33&rft.spage=13399&rft_id=info:doi/10.1073%2Fpnas.1104954108&rft_id=info%3Apmid%2F21808049&rft.externalDocID=21808049 |
thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F108%2F33.cover.gif |
thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F108%2F33.cover.gif |