Acute nicotine induces anxiety and disrupts temporal pattern organization of rat exploratory behavior in hole-board: a potential role for the lateral habenula

• Published in: Frontiers in cellular neuroscience Vol. 9; p. 197
• Main Authors: Casarrubea, Maurizio, Davies, Caitlin, Faulisi, Fabiana, Pierucci, Massimo, Colangeli, Roberto, Partridge, Lucy, Chambers, Stephanie, Cassar, Daniel, Valentino, Mario, Muscat, Richard, Benigno, Arcangelo, Crescimanno, Giuseppe, Di Giovanni, Giuseppe
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 01.06.2015; Frontiers Media S.A
• Subjects: Addictions; Addictive behaviors; Animals; Anxiety; Anxiolytics; Aversion; Behavior; Dopamine; Drug abuse; Drug addiction; Emotional behavior; Exploratory behavior; Grooming; Habenula; Lateral habenula; Luteinizing hormone; Neuroscience; Nicotine; Physiology; Rodents; Serotonin; Smoking; T-pattern analysis; Tobacco smoking; United Kingdom > UK; anxiety; T-pattern analysis; nicotine; serotonin; dopamine; lateral habenula

Nicotine is one of the most addictive drugs of abuse. Tobacco smoking is a major cause of many health problems, and is the first preventable cause of death worldwide. Several findings show that nicotine exerts significant aversive as well as the well-known rewarding motivational effects. Less certai...