Photosensitizer spatial heterogeneity and its impact on personalized interstitial photodynamic therapy treatment planning

• Published in: Journal of biomedical optics Vol. 30; no. 1; p. 018001
• Main Authors: Saeidi, Tina, Wang, Shuran, Contreras, Hector A., Daly, Michael J., Betz, Vaughn, Lilge, Lothar
• Format: Journal Article
• Language: English
• Published: United States Society of Photo-Optical Instrumentation Engineers 01.01.2025; SPIE
• Subjects: Animals; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - drug therapy; Cancer; Cell Line, Tumor; Glioblastoma - diagnostic imaging; Glioblastoma - drug therapy; Glioma - diagnostic imaging; Glioma - drug therapy; Humans; Photochemotherapy; Photochemotherapy - methods; Photosensitizing Agents - pharmacokinetics; Photosensitizing Agents - therapeutic use; Precision Medicine - methods; Rats; Therapeutic; photosensitizer heterogeneity; PDT-SPACE; interstitial photodynamic therapy; pre-treatment planning

Personalized photodynamic therapy (PDT) treatment planning requires knowledge of the spatial and temporal co-localization of photons, photosensitizers (PSs), and oxygen. The inter- and intra-subject variability in the photosensitizer concentration can lead to suboptimal outcomes using standard treat...