Evaluation of the time resolved fluorescence immunoassay (TRFIA) for the detection of varicella zoster virus (VZV) antibodies following vaccination of healthcare workers

• Published in: Journal of virological methods Vol. 172; no. 1; pp. 60 - 65
• Main Authors: McDonald, S.L.R., Maple, P.A.C., Andrews, N., Brown, K.E., Ayres, K.L., Scott, F.T., Al Bassam, M., Gershon, A.A., Steinberg, S.P., Breuer, J.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.03.2011; Elsevier
• Subjects: Adult; Antibodies; Antibodies, Viral - blood; Antibody; Antibody Affinity - immunology; antibody detection; antigens; Avidity; Biological and medical sciences; Chickenpox - prevention & control; Female; Fluorescence; Fluorescent Antibody to Membrane Antigen; Fluoroimmunoassay - standards; Fundamental and applied biological sciences. Psychology; health care workers; Health Personnel; Herpesvirus 3, Human - immunology; Human herpesvirus 3; Humans; Immunity; Immunization; Immunoassays; Male; Medical personnel; Microbiology; Middle Aged; normal values; patients; risk; Risk factors; Sensitivity and Specificity; Seroconversion; Techniques used in virology; Time-resolved fluorescence immunoassay; Vaccination; Vaccines; Varicella; Varicella zoster virus; Virology; vOka vaccine; United Kingdom; Varicella zoster virus; Fluorescent Antibody to Membrane Antigen; VZV; Antibody; TRFIA; vOka vaccine; ROC; Time-resolved fluorescence immunoassay; VZIG; FAMA; Herpesviridae; Vaccination; Alphaherpesvirinae; Health care staff; Vaccine; Method; Virus; Antigen; Time resolution; Detection

Determination of varicella zoster virus (VZV) immunity in healthcare workers without a history of chickenpox is important for identifying those in need of vOka vaccination. Post immunisation, healthcare workers in the UK who work with high risk patients are tested for seroconversion. To assess the p...