The Oncofetal Domain of Fibronectin Defined by Monoclonal Antibody FDC-6: Its Presence in Fibronectins from Fetal and Tumor Tissues and Its Absence in Those from Normal Adult Tissues and Plasma

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 82; no. 19; pp. 6517 - 6521
• Main Authors: Matsuura, Hidemitsu, Hakomori, Sen-Itiroh
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 01.10.1985; National Acad Sciences
• Subjects: Analytical, structural and metabolic biochemistry; Animals; Antibodies; Antibodies, Monoclonal - immunology; Antibody Specificity; Antigens, Neoplasm - genetics; Antigens, Neoplasm - immunology; Biological and medical sciences; Carcinoma, Hepatocellular - analysis; Cell Line; Connective Tissue - analysis; Connective tissues; Cultured cells; Female; Fetus; Fetus - analysis; Fibroblasts; Fibroblasts - analysis; Fibronectins - genetics; Fibronectins - immunology; Fibronectins - isolation & purification; Fundamental and applied biological sciences. Psychology; Gels; Glycoproteins; Hepatocellular carcinoma; Humans; Immunoglobulin G - immunology; Liver Neoplasms; Male; Mice; Molecular weight; Monoclonal antibodies; Neoplasm Proteins - immunology; Peptides - analysis; Placenta - analysis; Pregnancy; Proteins; Reactivity; Skin - analysis; Human; Molecular structure; Adult; Fetus; Serum; Tumor; Identification; Monoclonal antibody; Comparative study; Fibronectin

An IgG1 monoclonal antibody, FDC-6, was established, which defines a unique fibronectin (FN) domain, located between the ``Hep-2'' and the ``Fib-2'' domains, in the COOH-terminal region of FNs isolated from hepatoma, sarcoma, and fetal fibroblasts. A systematic study with this an...