Sclerotiorin inhibits protein kinase G from Mycobacterium tuberculosis and impairs mycobacterial growth in macrophages - Chen, Dongni; Ma, Shuangshuang; He, Lei; Yuan, Peibo; She, Zhigang; Lu, Yongjun (Tuberculosis (Edinburgh, Scotland), 2017)
Keywords: Animals; Anti-tuberculosis; Antibiotics; Antitubercular Agents - chemistry; Antitubercular Agents - metabolism; Antitubercular Agents - pharmacology; Azaphilone; Bacterial Load; Bacterial Proteins - antagonists & inhibitors; Bacterial Proteins - chemistry; Bacterial Proteins - metabolism; Benzopyrans - chemistry; Benzopyrans - metabolism; Benzopyrans - pharmacology; Binding; Binding Sites; Catalysis; Cell culture; Cell survival; Cytotoxicity; Development strategies; Docking; Dose-Response Relationship, Drug; Drug development; Eukaryotes; Fungi; HeLa Cells; Humans; Infectious Disease; Inhibitors; Kinases; Macrophages; Macrophages - drug effects; Macrophages - microbiology; MCF-7 Cells; Mice; Molecular Docking Simulation; Molecular Targeted Therapy; Mycobacterium bovis - drug effects; Mycobacterium bovis - enzymology; Mycobacterium bovis - growth & development; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - enzymology; Mycobacterium tuberculosis - growth & development; Protein Binding; Protein Interaction Domains and Motifs; Protein kinase; Protein kinase G; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - metabolism; Protein Kinase Inhibitors - pharmacology; Protein-Serine-Threonine Kinases - antagonists & inhibitors; Protein-Serine-Threonine Kinases - chemistry; Protein-Serine-Threonine Kinases - metabolism; Proteins; Pulmonary/Respiratory; Rifampin; Survival; Toxicity; Tuberculosis; Tuberculosis - drug therapy; Tuberculosis - microbiology; Viability; Azaphilone; Inhibitors; Macrophages; Anti-tuberculosis; Protein kinase G