Gene expression perturbation in vitro—A growing case for three-dimensional (3D) culture systems
Cells grown in vitro are dramatically perturbed by their new microenvironment. Analyses of genome-wide gene expression levels offer a first glance at which genes and pathways are affected in cell lines as compared to their tissues of origins. We have summarized available gene expression data and rev...
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Published in | Seminars in cancer biology Vol. 15; no. 5; pp. 405 - 412 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.10.2005
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Subjects | |
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Abstract | Cells grown in vitro are dramatically perturbed by their new microenvironment. Analyses of genome-wide gene expression levels offer a first glance at which genes and pathways are affected in cell lines as compared to their tissues of origins. We have summarized available gene expression data and review how cell lines adapt to in vitro environments, to what degree they express markers of their tissues of origins and discuss how cells grown in three-dimensional (3D) cultures may have more physiological interactions with neighbouring cells and extracellular matrix. We will also discuss the interplay between malignant cells and stroma present in tumours but lacking in cell lines and how these differences might affect gene expression comparisons of cell lines to tumours. A model simulating impact of stromal cells on gene expression profiles is presented. Understanding the transcriptomes of cells grown in 2D and 3D cultures and how they compare to those of in vivo cells are important for improving cell line model systems and for the reconstituting of tissues in vitro. |
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AbstractList | Cells grown in vitro are dramatically perturbed by their new microenvironment. Analyses of genome-wide gene expression levels offer a first glance at which genes and pathways are affected in cell lines as compared to their tissues of origins. We have summarized available gene expression data and review how cell lines adapt to in vitro environments, to what degree they express markers of their tissues of origins and discuss how cells grown in three-dimensional (3D) cultures may have more physiological interactions with neighbouring cells and extracellular matrix. We will also discuss the interplay between malignant cells and stroma present in tumours but lacking in cell lines and how these differences might affect gene expression comparisons of cell lines to tumours. A model simulating impact of stromal cells on gene expression profiles is presented. Understanding the transcriptomes of cells grown in 2D and 3D cultures and how they compare to those of in vivo cells are important for improving cell line model systems and for the reconstituting of tissues in vitro. |
Author | Birgersdotter, Anna Sandberg, Rickard Ernberg, Ingemar |
Author_xml | – sequence: 1 givenname: Anna surname: Birgersdotter fullname: Birgersdotter, Anna – sequence: 2 givenname: Rickard surname: Sandberg fullname: Sandberg, Rickard – sequence: 3 givenname: Ingemar surname: Ernberg fullname: Ernberg, Ingemar email: ingemar.ernberg@mtc.ki.se |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16055341$$D View this record in MEDLINE/PubMed http://kipublications.ki.se/Default.aspx?queryparsed=id:1931620$$DView record from Swedish Publication Index |
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SubjectTerms | 3-D cell culture Cancer cell lines Cell Adhesion Cell Line Cell Line, Tumor Cell Proliferation Coculture Techniques DNA - metabolism Down-Regulation Gene Expression Regulation, Neoplastic Global gene expression Humans Medicin och hälsovetenskap Neoplasm Metastasis Neoplasms - metabolism Oligonucleotide Array Sequence Analysis Phenotype Transcription, Genetic Transcriptome Tumor stroma Up-Regulation |
Title | Gene expression perturbation in vitro—A growing case for three-dimensional (3D) culture systems |
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