Breathomics to diagnose systemic sclerosis using thermal desorption and comprehensive two-dimensional gas chromatography high-resolution time-of-flight mass spectrometry

• Published in: Analytical and bioanalytical chemistry Vol. 413; no. 14; pp. 3813 - 3822
• Main Authors: Zanella, Delphine, Guiot, Julien, Stefanuto, Pierre-Hugues, Giltay, Laurie, Henket, Monique, Guissard, Françoise, André, Béatrice, Malaise, Michel, Potjewijd, Judith, Schleich, Florence, Louis, Renaud, Focant, Jean-François
• Format: Journal Article Web Resource
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2021; Springer; Springer Nature B.V
• Subjects: air; Air monitoring; Analytical Chemistry; Autoimmune diseases; Biochemistry; Biomarkers; Characterization and Evaluation of Materials; Chemical composition; Chemical compounds; Chemistry; Chemistry and Materials Science; Chimie; Chromatography; comprehensive two-dimensional gas chromatography; desorption; Diagnosis; Discriminant analysis; disease progression; disease severity; early diagnosis; Food Science; Gas chromatography; High resolution; Laboratory Medicine; Lung diseases; Mass spectrometry; Mass spectroscopy; Methods; Monitoring/Environmental Analysis; mortality; Organic compounds; Physical, chemical, mathematical & earth Sciences; Physique, chimie, mathématiques & sciences de la terre; prognosis; Research Paper; Resolution; respiratory tract diseases; Scientific imaging; Scleroderma; Scleroderma (Disease); sclerosis; Spectroscopy; Systemic scleroderma; Systemic sclerosis; t-test; Terpenes; terpenoids; Time-of-flight mass spectrometry; Two dimensional bodies; variance; VOCs; Volatile organic compounds; Belgium; Volatile organic compounds; Biomarkers; High-resolution mass spectrometry; Comprehensive two-dimensional gas chromatography; Systemic sclerosis; Exhaled breath

Systemic sclerosis is a rare autoimmune disease associated with rapidly evolving interstitial lung disease, responsible for the disease severity and mortality. Specific biomarkers enabling the early diagnosis and prognosis associated with the disease progression are highly needed. Volatile organic c...