Recurrent TERT promoter mutations in urothelial carcinoma and potential clinical applications

• Published in: Annals of diagnostic pathology Vol. 21; pp. 7 - 11
• Main Authors: Kurtis, Boaz, Zhuge, Jian, Ojaimi, Caroline, Ye, Fei, Cai, Dongming, Zhang, David, Fallon, John T., Zhong, Minghao
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2016
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Biomarkers, Tumor - urine; Carcinoma, Transitional Cell - diagnosis; Carcinoma, Transitional Cell - genetics; Diagnosis; Female; Humans; Male; Middle Aged; Mutation; Pathology; Promoter Regions, Genetic - genetics; Sequence Analysis, DNA; Telomerase - genetics; TERT promoter mutation; Urinary Bladder Neoplasms - diagnosis; Urinary Bladder Neoplasms - genetics; Urine; Urologic Neoplasms - diagnosis; Urologic Neoplasms - genetics; Urothelial carcinoma; Urothelium - pathology; Urine; TERT promoter mutation; Diagnosis; Urothelial carcinoma

Increased telomerase activity is associated with almost all types of advanced human cancers with unknown molecular mechanism(s). Two recurrent point mutations in the promoter region of telomerase reverse transcriptase (TERT)—the key subunit of telomerase—have recently been identified in melanoma as...