Improvement of Bone Regeneration Capability of Ceramic Scaffolds by Accelerated Release of Their Calcium Ions

To regenerate the bone tissue, the fabrication of scaffolds for better tissue regeneration has attracted a great deal of attention. In fact, growth factors are already used in clinical practice and are being investigated for enhancing the capacity for bone tissue regeneration. However, despite their...

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Published inTissue engineering. Part A Vol. 20; no. 21-22; pp. 284 - 2849
Main Authors Seol, Young-Joon, Park, Ju Young, Jung, Jin Woo, Jang, Jinah, Girdhari, Rijal, Kim, Sung Won, Cho, Dong-Woo
Format Journal Article
LanguageEnglish
Published United States Mary Ann Liebert, Inc 01.11.2014
Subjects
Animals
Biomedical materials
Bone Regeneration - drug effects
Bone Regeneration - physiology
Bone Substitutes - chemical synthesis
Bones
Calcium
Calcium - chemistry
Calcium - pharmacology
Ceramics
Ceramics - chemistry
Equipment Failure Analysis
Guided Tissue Regeneration - instrumentation
Ions
Male
Materials Testing
Original
Original Articles
Prosthesis Design
Rats
Rats, Sprague-Dawley
Skull Fractures - pathology
Skull Fractures - physiopathology
Skull Fractures - surgery
Tissue engineering
Tissue Scaffolds
Treatment Outcome
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Abstract To regenerate the bone tissue, the fabrication of scaffolds for better tissue regeneration has attracted a great deal of attention. In fact, growth factors are already used in clinical practice and are being investigated for enhancing the capacity for bone tissue regeneration. However, despite their strong osteoinductive activity, these growth factors have several limitations: safety issues, high treatment costs, and the potential for ectopic bone formation. The aim of this study was therefore to develop ceramic scaffolds that could promote the capacity for bone regeneration without growth factors. Three-dimensional ceramic scaffolds were successfully fabricated from hydroxyapatite (HA) and tricalcium phosphate (TCP) using projection-based microstereolithography, which is an additive manufacturing technology. The effects of calcium ions released from ceramic scaffolds on osteogenic differentiation and bone regeneration were evaluated in vitro and in vivo . The osteogenesis-related gene expression and area of new bone formation in the HA/TCP scaffolds was higher than those in the HA scaffolds. Moreover, regenerated bone tissue in HA/TCP scaffolds were more matured than that in HA scaffolds. Through this study, we were able to enhance the bone regeneration capacity of scaffolds not by growth factors but by calcium ions released from the scaffolds. Ceramic scaffolds developed in this study might be useful for enhancing the capacity for regeneration in complex bone defects.
AbstractList To regenerate the bone tissue, the fabrication of scaffolds for better tissue regeneration has attracted a great deal of attention. In fact, growth factors are already used in clinical practice and are being investigated for enhancing the capacity for bone tissue regeneration. However, despite their strong osteoinductive activity, these growth factors have several limitations: safety issues, high treatment costs, and the potential for ectopic bone formation. The aim of this study was therefore to develop ceramic scaffolds that could promote the capacity for bone regeneration without growth factors. Three-dimensional ceramic scaffolds were successfully fabricated from hydroxyapatite (HA) and tricalcium phosphate (TCP) using projection-based microstereolithography, which is an additive manufacturing technology. The effects of calcium ions released from ceramic scaffolds on osteogenic differentiation and bone regeneration were evaluated in vitro and in vivo . The osteogenesis-related gene expression and area of new bone formation in the HA/TCP scaffolds was higher than those in the HA scaffolds. Moreover, regenerated bone tissue in HA/TCP scaffolds were more matured than that in HA scaffolds. Through this study, we were able to enhance the bone regeneration capacity of scaffolds not by growth factors but by calcium ions released from the scaffolds. Ceramic scaffolds developed in this study might be useful for enhancing the capacity for regeneration in complex bone defects.
To regenerate the bone tissue, the fabrication of scaffolds for better tissue regeneration has attracted a great deal of attention. In fact, growth factors are already used in clinical practice and are being investigated for enhancing the capacity for bone tissue regeneration. However, despite their strong osteoinductive activity, these growth factors have several limitations: safety issues, high treatment costs, and the potential for ectopic bone formation. The aim of this study was therefore to develop ceramic scaffolds that could promote the capacity for bone regeneration without growth factors. Three-dimensional ceramic scaffolds were successfully fabricated from hydroxyapatite (HA) and tricalcium phosphate (TCP) using projection-based microstereolithography, which is an additive manufacturing technology. The effects of calcium ions released from ceramic scaffolds on osteogenic differentiation and bone regeneration were evaluated in vitro and in vivo. The osteogenesis-related gene expression and area of new bone formation in the HA/TCP scaffolds was higher than those in the HA scaffolds. Moreover, regenerated bone tissue in HA/TCP scaffolds were more matured than that in HA scaffolds. Through this study, we were able to enhance the bone regeneration capacity of scaffolds not by growth factors but by calcium ions released from the scaffolds. Ceramic scaffolds developed in this study might be useful for enhancing the capacity for regeneration in complex bone defects.
Author Jang, Jinah
Girdhari, Rijal
Park, Ju Young
Cho, Dong-Woo
Seol, Young-Joon
Jung, Jin Woo
Kim, Sung Won
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Snippet To regenerate the bone tissue, the fabrication of scaffolds for better tissue regeneration has attracted a great deal of attention. In fact, growth factors are...
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pubmed
maryannliebert
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StartPage 284
SubjectTerms Animals
Biomedical materials
Bone Regeneration - drug effects
Bone Regeneration - physiology
Bone Substitutes - chemical synthesis
Bones
Calcium
Calcium - chemistry
Calcium - pharmacology
Ceramics
Ceramics - chemistry
Equipment Failure Analysis
Guided Tissue Regeneration - instrumentation
Ions
Male
Materials Testing
Original
Original Articles
Prosthesis Design
Rats
Rats, Sprague-Dawley
Skull Fractures - pathology
Skull Fractures - physiopathology
Skull Fractures - surgery
Tissue engineering
Tissue Scaffolds
Treatment Outcome
Title Improvement of Bone Regeneration Capability of Ceramic Scaffolds by Accelerated Release of Their Calcium Ions
URI https://www.liebertpub.com/doi/abs/10.1089/ten.tea.2012.0726
https://www.ncbi.nlm.nih.gov/pubmed/24784792
https://www.proquest.com/docview/1622858571
https://search.proquest.com/docview/1625343185
https://search.proquest.com/docview/1635031903
https://pubmed.ncbi.nlm.nih.gov/PMC4229868
Volume 20
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