Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 28; pp. 16587 - 16595
• Main Authors: Imai, Masaki, Iwatsuki-Horimoto, Kiyoko, Hatta, Masato, Loeber, Samantha, Halfmann, Peter J., Nakajima, Noriko, Watanabe, Tokiko, Ujie, Michiko, Takahashi, Kenta, Ito, Mutsumi, Yamada, Shinya, Fan, Shufang, Chiba, Shiho, Kuroda, Makoto, Guan, Lizheng, Takada, Kosuke, Armbrust, Tammy, Balogh, Aaron, Furusawa, Yuri, Okuda, Moe, Ueki, Hiroshi, Yasuhara, Atsuhiro, Sakai-Tagawa, Yuko, Lopes, Tiago J. S., Kiso, Maki, Yamayoshi, Seiya, Kinoshita, Noriko, Ohmagari, Norio, Hattori, Shin-ichiro, Takeda, Makoto, Mitsuya, Hiroaki, Krammer, Florian, Suzuki, Tadaki, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: Washington National Academy of Sciences 14.07.2020
• Subjects: Animal models; Antibodies; Antiviral agents; Biological Sciences; Computed tomography; Coronaviridae; Coronaviruses; COVID-19; Global economy; Hamsters; Lungs; Opacity; Pathogenesis; Respiratory diseases; Rodents; Severe acute respiratory syndrome coronavirus 2; Vaccines; Viral diseases; Viruses

At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around the world, with severe consequences for human health and the global economy. Here, we assessed the replicative ability and pathogenesis of SA...