Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development
At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around the world, with severe consequences for human health and the global economy. Here, we assessed the replicative ability and pathogenesis of SA...
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| Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 28; pp. 16587 - 16595 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington
National Academy of Sciences
14.07.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around the world, with severe consequences for human health and the global economy. Here, we assessed the replicative ability and pathogenesis of SARS-CoV-2 isolates in Syrian hamsters. SARS-CoV-2 isolates replicated efficiently in the lungs of hamsters, causing severe pathological lung lesions following intranasal infection. In addition, microcomputed tomographic imaging revealed severe lung injury that shared characteristics with SARS-CoV-2−infected human lung, including severe, bilateral, peripherally distributed, multilobular ground glass opacity, and regions of lung consolidation. SARS-CoV-2−infected hamsters mounted neutralizing antibody responses and were protected against subsequent rechallenge with SARS-CoV-2. Moreover, passive transfer of convalescent serum to naïve hamsters efficiently suppressed the replication of the virus in the lungs even when the serum was administrated 2 d postinfection of the serum-treated hamsters. Collectively, these findings demonstrate that this Syrian hamster model will be useful for understanding SARS-CoV-2 pathogenesis and testing vaccines and antiviral drugs. |
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| AbstractList | Since SARS-CoV-2 emerged in China, it has spread rapidly around the world. Effective vaccines and therapeutics for SARS-CoV-2−induced disease (coronavirus disease 2019;COVID-19) are urgently needed. We found that SARS-CoV-2 isolates replicate efficiently in the lungs of Syrian hamsters and cause severe pathological lesions in the lungs of these animals similar to commonly reported imaging features of COVID-19 patients with pneumonia. SARS-CoV-2−infected hamsters mounted neutralizing antibody responses and were protected against rechallenge with SARS-CoV-2. Moreover, passive transfer of convalescent serum to naïve hamsters inhibited virus replication in their lungs. Syrian hamsters are a useful small animal model for the evaluation of vaccines, immunotherapies, and antiviral drugs.
At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around the world, with severe consequences for human health and the global economy. Here, we assessed the replicative ability and pathogenesis of SARS-CoV-2 isolates in Syrian hamsters. SARS-CoV-2 isolates replicated efficiently in the lungs of hamsters, causing severe pathological lung lesions following intranasal infection. In addition, microcomputed tomographic imaging revealed severe lung injury that shared characteristics with SARS-CoV-2−infected human lung, including severe, bilateral, peripherally distributed, multilobular ground glass opacity, and regions of lung consolidation. SARS-CoV-2−infected hamsters mounted neutralizing antibody responses and were protected against subsequent rechallenge with SARS-CoV-2. Moreover, passive transfer of convalescent serum to naïve hamsters efficiently suppressed the replication of the virus in the lungs even when the serum was administrated 2 d postinfection of the serum-treated hamsters. Collectively, these findings demonstrate that this Syrian hamster model will be useful for understanding SARS-CoV-2 pathogenesis and testing vaccines and antiviral drugs. At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around the world, with severe consequences for human health and the global economy. Here, we assessed the replicative ability and pathogenesis of SARS-CoV-2 isolates in Syrian hamsters. SARS-CoV-2 isolates replicated efficiently in the lungs of hamsters, causing severe pathological lung lesions following intranasal infection. In addition, microcomputed tomographic imaging revealed severe lung injury that shared characteristics with SARS-CoV-2-infected human lung, including severe, bilateral, peripherally distributed, multilobular ground glass opacity, and regions of lung consolidation. SARS-CoV-2-infected hamsters mounted neutralizing antibody responses and were protected against subsequent rechallenge with SARS-CoV-2. Moreover, passive transfer of convalescent serum to naïve hamsters efficiently suppressed the replication of the virus in the lungs even when the serum was administrated 2 d postinfection of the serum-treated hamsters. Collectively, these findings demonstrate that this Syrian hamster model will be useful for understanding SARS-CoV-2 pathogenesis and testing vaccines and antiviral drugs.At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around the world, with severe consequences for human health and the global economy. Here, we assessed the replicative ability and pathogenesis of SARS-CoV-2 isolates in Syrian hamsters. SARS-CoV-2 isolates replicated efficiently in the lungs of hamsters, causing severe pathological lung lesions following intranasal infection. In addition, microcomputed tomographic imaging revealed severe lung injury that shared characteristics with SARS-CoV-2-infected human lung, including severe, bilateral, peripherally distributed, multilobular ground glass opacity, and regions of lung consolidation. SARS-CoV-2-infected hamsters mounted neutralizing antibody responses and were protected against subsequent rechallenge with SARS-CoV-2. Moreover, passive transfer of convalescent serum to naïve hamsters efficiently suppressed the replication of the virus in the lungs even when the serum was administrated 2 d postinfection of the serum-treated hamsters. Collectively, these findings demonstrate that this Syrian hamster model will be useful for understanding SARS-CoV-2 pathogenesis and testing vaccines and antiviral drugs. At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around the world, with severe consequences for human health and the global economy. Here, we assessed the replicative ability and pathogenesis of SARS-CoV-2 isolates in Syrian hamsters. SARS-CoV-2 isolates replicated efficiently in the lungs of hamsters, causing severe pathological lung lesions following intranasal infection. In addition, microcomputed tomographic imaging revealed severe lung injury that shared characteristics with SARS-CoV-2−infected human lung, including severe, bilateral, peripherally distributed, multilobular ground glass opacity, and regions of lung consolidation. SARS-CoV-2−infected hamsters mounted neutralizing antibody responses and were protected against subsequent rechallenge with SARS-CoV-2. Moreover, passive transfer of convalescent serum to naïve hamsters efficiently suppressed the replication of the virus in the lungs even when the serum was administrated 2 d postinfection of the serum-treated hamsters. Collectively, these findings demonstrate that this Syrian hamster model will be useful for understanding SARS-CoV-2 pathogenesis and testing vaccines and antiviral drugs. |
| Author | Armbrust, Tammy Krammer, Florian Takeda, Makoto Lopes, Tiago J. S. Ohmagari, Norio Kinoshita, Noriko Watanabe, Tokiko Ueki, Hiroshi Yamayoshi, Seiya Furusawa, Yuri Hattori, Shin-ichiro Nakajima, Noriko Imai, Masaki Takahashi, Kenta Loeber, Samantha Kuroda, Makoto Suzuki, Tadaki Balogh, Aaron Okuda, Moe Iwatsuki-Horimoto, Kiyoko Ujie, Michiko Yasuhara, Atsuhiro Halfmann, Peter J. Mitsuya, Hiroaki Kiso, Maki Takada, Kosuke Guan, Lizheng Kawaoka, Yoshihiro Hatta, Masato Sakai-Tagawa, Yuko Ito, Mutsumi Yamada, Shinya Fan, Shufang Chiba, Shiho |
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| Cites_doi | 10.1016/S0140-6736(20)30183-5 10.1128/JVI.78.7.3572-3577.2004 10.1126/science.abb7015 10.1038/s41586-020-2012-7 10.1016/j.jinf.2020.03.005 10.1016/0042-6822(90)90426-R 10.1001/jama.2020.6775 10.1001/jamaneurol.2020.1127 10.3201/eid2606.200516 10.1007/s00330-020-06801-0 10.1128/JVI.00645-06 10.1083/jcb.131.2.339 10.1148/ryct.2020200152 10.1073/pnas.2002589117 10.1016/j.cell.2020.02.052 10.15585/mmwr.mm6912e2 10.1001/jamaophthalmol.2020.1291 10.1086/500143 10.1056/NEJMoa2001017 10.1016/j.bbrc.2020.03.047 10.1128/JVI.00304-08 10.1128/JVI.00737-08 10.1093/cid/ciaa325 10.1126/science.abb7314 10.1148/radiol.2020200230 10.1016/j.cmi.2020.03.025 10.1056/NEJMc032421 10.1128/JVI.79.1.503-511.2005 10.1016/j.virol.2006.11.027 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 1M. Imai, K.I.-H., M.H., S.L., P.J.H., and N.N. contributed equally to this work. Author contributions: M. Imai, K.I.-H., M.H., S.L., P.J.H., N.N., and Y.K. designed research; M. Imai, K.I.-H., M.H., P.J.H., T.W., M.U., M. Ito, S. Yamada, S.F., S.C., M. Kuroda, L.G., K. Takada, T.A., A.B., Y.F., M.O., H.U., A.Y., Y.S.-T., M. Kiso, and S. Yamayoshi performed research; N.K., N.O., S.-i.H., M.T., H.M., and F.K. contributed new reagents/analytic tools; M. Imai, K.I.-H., M.H., S.L., P.J.H., N.N., K. Takahashi, T.J.S.L., T.S., and Y.K. analyzed data; M. Imai, K.I.-H., M.H., S.L., P.J.H., N.N., and Y.K. wrote the paper; N.K., N.O., S.-i.H., and H.M. provided the clinical samples; M.T. provided the VeroE6/TMPRSS2 cells; and F.K. provided the plasmid encoding the receptor-binding domain (RBD) of SARS-CoV-2. Edited by Robert L. Coffman, University of California, Santa Cruz, CA, and approved June 12, 2020 (received for review May 15, 2020) |
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| SubjectTerms | Animal models Antibodies Antiviral agents Biological Sciences Computed tomography Coronaviridae Coronaviruses COVID-19 Global economy Hamsters Lungs Opacity Pathogenesis Respiratory diseases Rodents Severe acute respiratory syndrome coronavirus 2 Vaccines Viral diseases Viruses |
| Title | Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development |
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