DNA methylation dynamics, metabolic fluxes, gene splicing, and alternative phenotypes in honey bees

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 13; pp. 4968 - 4973
• Main Authors: Foret, Sylvain, Kucharski, Robert, Pellegrini, Matteo, Feng, Suhua, Jacobsen, Steven E., Robinson, Gene E., Maleszka, Ryszard
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.03.2012; National Acad Sciences
• Subjects: adults; Aging; Aging - genetics; Alternative splicing; Animals; Antisense; Apis; Apis mellifera; Bees; Bees - genetics; Biological Sciences; Brain; Caste determination; Citric Acid Cycle; Citric Acid Cycle - genetics; Data processing; Deoxyribonucleic acid; Development; Diet; Dietary intake; DNA; DNA methylation; DNA Methylation - genetics; DNA methyltransferase; DNA-directed RNA polymerase; Exons; Feeding; Gene Expression Profiling; genes; Genes, Insect; Genes, Insect - genetics; Genetics; Genotype & phenotype; Head; Hierarchy, Social; Honey; Honey bees; Hormones; Insect castes; Insect genetics; Insect larvae; Insect Proteins; Insect Proteins - genetics; Insect Proteins - metabolism; Insulin; Juvenile hormones; Larva; Larva - genetics; Larvae; Larval development; Lymphoma; metabolic flux; Metabolic Networks and Pathways; Metabolic Networks and Pathways - genetics; Metabolism; Methylation; methyltransferases; Models, Genetic; Molecular Sequence Annotation; Nodes; nutrition; Organ Specificity; Organ Specificity - genetics; Phenotype; Proteasome Endopeptidase Complex; Proteasome Endopeptidase Complex - metabolism; Protein-tyrosine kinase; Queen honey bees; Queens; RNA Splicing; RNA Splicing - genetics; RNA-protein interactions; Royal jelly; Signal Transduction; Signal Transduction - genetics; Spliceosomes; Spliceosomes - metabolism; Transcription; Ubiquitin; Ubiquitin - metabolism; Workers

In honey bees (Apis mellifera), the development of a larva into either a queen or worker depends on differential feeding with royal jelly and involves epigenomic modifications by DNA methyltransferases. To understand the role of DNA methylation in this process we sequenced the larval methylomes in b...