Long non-coding RNA-polycomb intimate rendezvous

• Published in: Open biology Vol. 10; no. 9; p. 200126
• Main Authors: Cerase, Andrea, Tartaglia, Gian Gaetano
• Format: Journal Article
• Language: English
• Published: The Royal Society 01.09.2020
• Subjects: hotair rna; long non-coding rnas (lncrna); phase separation; polycomb-repressive complexes 1/2 (prc1/2); Review; rna secondary structure; rna–protein interaction; xist rna

The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate. While cross-linking, immuno-precipitation and super-resolution m...