Real-time maps of fluid flow fields in porous biomaterials

Abstract Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells is limited because the local flow patterns and associated metrics are not precisely known. Here we present real-time, non-invasive measures of...

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Published in	Biomaterials Vol. 34; no. 8; pp. 1980 - 1986
Main Authors	Mack, Julia J, Youssef, Khalid, Noel, Onika D.V, Lake, Michael P, Wu, Ashley, Iruela-Arispe, M. Luisa, Bouchard, Louis-S
Format	Journal Article
Language	English
Published	Netherlands Elsevier Ltd 01.03.2013
Subjects	3D scaffold Advanced Basic Science Biocompatible Materials - chemistry Biomaterials Biomedical materials Biopolymers - chemistry Computer Systems Dentistry Extracellular Fluid - physiology Flow Fluid dynamics Fluid flow Fluid permeability Fluids Hydrodynamics Hydrogel Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Magnetic Resonance Spectroscopy NMR Polyesters - chemistry Porosity Rheology Shear Surgical implants Three dimensional Tissue Scaffolds - chemistry NMR Hydrogel 3D scaffold Fluid permeability Flow
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Abstract	Abstract Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells is limited because the local flow patterns and associated metrics are not precisely known. Here we present real-time, non-invasive measures of local hydrodynamics in 3D biomaterials based on nuclear magnetic resonance. Microflow maps were further used to derive pressure, shear and fluid permeability fields. Finally, remodeling of collagen gels in response to precise fluid flow parameters was correlated with structural changes. It is anticipated that accurate flow maps within 3D matrices will be a critical step towards understanding cell behavior in response to controlled flow dynamics.
AbstractList	Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells is limited because the local flow patterns and associated metrics are not precisely known. Here we present real-time, non-invasive measures of local hydrodynamics in 3D biomaterials based on nuclear magnetic resonance. Microflow maps were further used to derive pressure, shear and fluid permeability fields. Finally, remodeling of collagen gels in response to precise fluid flow parameters was correlated with structural changes. It is anticipated that accurate flow maps within 3D matrices will be a critical step towards understanding cell behavior in response to controlled flow dynamics. Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells is limited because the local flow patterns and associated metrics are not precisely known. Here we present real-time, noninvasive measures of local hydrodynamics in 3D biomaterials based on nuclear magnetic resonance. Microflow maps were further used to derive pressure, shear and fluid permeability fields. Finally, remodeling of collagen gels in response to precise fluid flow parameters was correlated with structural changes. It is anticipated that accurate flow maps within 3D matrices will be a critical step towards understanding cell behavior in response to controlled flow dynamics. Abstract Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells is limited because the local flow patterns and associated metrics are not precisely known. Here we present real-time, non-invasive measures of local hydrodynamics in 3D biomaterials based on nuclear magnetic resonance. Microflow maps were further used to derive pressure, shear and fluid permeability fields. Finally, remodeling of collagen gels in response to precise fluid flow parameters was correlated with structural changes. It is anticipated that accurate flow maps within 3D matrices will be a critical step towards understanding cell behavior in response to controlled flow dynamics.
Author	Iruela-Arispe, M. Luisa Mack, Julia J Wu, Ashley Youssef, Khalid Noel, Onika D.V Lake, Michael P Bouchard, Louis-S
AuthorAffiliation	3 California NanoSystems Institute, University of California, Los Angeles, CA 90095 4 Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, CA 90095 1 Department of Chemistry and Biochemistry, University of C alifornia, Los Angeles, CA 90095 5 Molecular Biology Institute, University of California, Los Angeles, CA 90095 2 Department of Bioengineering, University of California, Los Angeles, CA 90095
AuthorAffiliation_xml	– name: 4 Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, CA 90095 – name: 1 Department of Chemistry and Biochemistry, University of C alifornia, Los Angeles, CA 90095 – name: 3 California NanoSystems Institute, University of California, Los Angeles, CA 90095 – name: 5 Molecular Biology Institute, University of California, Los Angeles, CA 90095 – name: 2 Department of Bioengineering, University of California, Los Angeles, CA 90095
Author_xml	– sequence: 1 fullname: Mack, Julia J – sequence: 2 fullname: Youssef, Khalid – sequence: 3 fullname: Noel, Onika D.V – sequence: 4 fullname: Lake, Michael P – sequence: 5 fullname: Wu, Ashley – sequence: 6 fullname: Iruela-Arispe, M. Luisa – sequence: 7 fullname: Bouchard, Louis-S
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Snippet	Abstract Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells... Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells is limited...
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SubjectTerms	3D scaffold Advanced Basic Science Biocompatible Materials - chemistry Biomaterials Biomedical materials Biopolymers - chemistry Computer Systems Dentistry Extracellular Fluid - physiology Flow Fluid dynamics Fluid flow Fluid permeability Fluids Hydrodynamics Hydrogel Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Magnetic Resonance Spectroscopy NMR Polyesters - chemistry Porosity Rheology Shear Surgical implants Three dimensional Tissue Scaffolds - chemistry
Title	Real-time maps of fluid flow fields in porous biomaterials
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