Real-time maps of fluid flow fields in porous biomaterials
Abstract Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells is limited because the local flow patterns and associated metrics are not precisely known. Here we present real-time, non-invasive measures of...
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Published in | Biomaterials Vol. 34; no. 8; pp. 1980 - 1986 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
01.03.2013
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Abstract | Abstract Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells is limited because the local flow patterns and associated metrics are not precisely known. Here we present real-time, non-invasive measures of local hydrodynamics in 3D biomaterials based on nuclear magnetic resonance. Microflow maps were further used to derive pressure, shear and fluid permeability fields. Finally, remodeling of collagen gels in response to precise fluid flow parameters was correlated with structural changes. It is anticipated that accurate flow maps within 3D matrices will be a critical step towards understanding cell behavior in response to controlled flow dynamics. |
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AbstractList | Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells is limited because the local flow patterns and associated metrics are not precisely known. Here we present real-time, non-invasive measures of local hydrodynamics in 3D biomaterials based on nuclear magnetic resonance. Microflow maps were further used to derive pressure, shear and fluid permeability fields. Finally, remodeling of collagen gels in response to precise fluid flow parameters was correlated with structural changes. It is anticipated that accurate flow maps within 3D matrices will be a critical step towards understanding cell behavior in response to controlled flow dynamics. Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells is limited because the local flow patterns and associated metrics are not precisely known. Here we present real-time, noninvasive measures of local hydrodynamics in 3D biomaterials based on nuclear magnetic resonance. Microflow maps were further used to derive pressure, shear and fluid permeability fields. Finally, remodeling of collagen gels in response to precise fluid flow parameters was correlated with structural changes. It is anticipated that accurate flow maps within 3D matrices will be a critical step towards understanding cell behavior in response to controlled flow dynamics. Abstract Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells is limited because the local flow patterns and associated metrics are not precisely known. Here we present real-time, non-invasive measures of local hydrodynamics in 3D biomaterials based on nuclear magnetic resonance. Microflow maps were further used to derive pressure, shear and fluid permeability fields. Finally, remodeling of collagen gels in response to precise fluid flow parameters was correlated with structural changes. It is anticipated that accurate flow maps within 3D matrices will be a critical step towards understanding cell behavior in response to controlled flow dynamics. |
Author | Iruela-Arispe, M. Luisa Mack, Julia J Wu, Ashley Youssef, Khalid Noel, Onika D.V Lake, Michael P Bouchard, Louis-S |
AuthorAffiliation | 3 California NanoSystems Institute, University of California, Los Angeles, CA 90095 4 Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, CA 90095 1 Department of Chemistry and Biochemistry, University of C alifornia, Los Angeles, CA 90095 5 Molecular Biology Institute, University of California, Los Angeles, CA 90095 2 Department of Bioengineering, University of California, Los Angeles, CA 90095 |
AuthorAffiliation_xml | – name: 4 Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, CA 90095 – name: 1 Department of Chemistry and Biochemistry, University of C alifornia, Los Angeles, CA 90095 – name: 3 California NanoSystems Institute, University of California, Los Angeles, CA 90095 – name: 5 Molecular Biology Institute, University of California, Los Angeles, CA 90095 – name: 2 Department of Bioengineering, University of California, Los Angeles, CA 90095 |
Author_xml | – sequence: 1 fullname: Mack, Julia J – sequence: 2 fullname: Youssef, Khalid – sequence: 3 fullname: Noel, Onika D.V – sequence: 4 fullname: Lake, Michael P – sequence: 5 fullname: Wu, Ashley – sequence: 6 fullname: Iruela-Arispe, M. Luisa – sequence: 7 fullname: Bouchard, Louis-S |
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Snippet | Abstract Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells... Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells is limited... |
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SubjectTerms | 3D scaffold Advanced Basic Science Biocompatible Materials - chemistry Biomaterials Biomedical materials Biopolymers - chemistry Computer Systems Dentistry Extracellular Fluid - physiology Flow Fluid dynamics Fluid flow Fluid permeability Fluids Hydrodynamics Hydrogel Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Magnetic Resonance Spectroscopy NMR Polyesters - chemistry Porosity Rheology Shear Surgical implants Three dimensional Tissue Scaffolds - chemistry |
Title | Real-time maps of fluid flow fields in porous biomaterials |
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