Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis

• Published in: Journal of pharmaceutical analysis Vol. 13; no. 7; pp. 817 - 829
• Main Authors: Chen, Jiayun, He, Xueling, Bai, Yunmeng, Liu, Jing, Wong, Yin Kwan, Xie, Lulin, Zhang, Qian, Luo, Piao, Gao, Peng, Gu, Liwei, Guo, Qiuyan, Cheng, Guangqing, Wang, Chen, Wang, Jigang
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.07.2023; Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,and Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China%State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China%Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,and Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China%Department of Gastroenterology,Shenzhen Hospital,Southern Medical University,Shenzhen,Guangdong,518020,China; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China; Xi'an Jiaotong University; Elsevier
• Subjects: Artesunate; Immunomodulatory activity; Original; Sepsis; Single-cell RNA sequencing; Sepsis; Immunomodulatory activity; Single-cell RNA sequencing; Artesunate

Sepsis is characterized by a severe and life-threatening host immune response to polymicrobial infection accompanied by organ dysfunction. Studies on the therapeutic effect and mechanism of immunomodulatory drugs on the sepsis-induced hyperinflammatory or immunosuppression states of various immune c...