Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation
In the recent years numerous studies have provided encouraging results supporting the use of transcranial direct current stimulation (tDCS) as non-invasive brain stimulation technique to improve motor and cognitive functions in patients suffering from neurological and neuropsychiatric disorders as w...
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| Published in | Frontiers in neuroscience Vol. 12; p. 427 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Research Foundation
26.06.2018
Frontiers Media S.A |
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| Online Access | Get full text |
| ISSN | 1662-453X 1662-4548 1662-453X |
| DOI | 10.3389/fnins.2018.00427 |
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| Abstract | In the recent years numerous studies have provided encouraging results supporting the use of transcranial direct current stimulation (tDCS) as non-invasive brain stimulation technique to improve motor and cognitive functions in patients suffering from neurological and neuropsychiatric disorders as well as in healthy subjects. Among the multiple effects elicited by tDCS on cognitive functions, experimental evidence and clinical findings have highlighted the beneficial impact on long-term memory. Memory deficits occur during physiological aging as well as in neurological and neurodegenerative disorders, including Alzheimer's disease (AD). In this scenario, non-invasive techniques for memory enhancement, such as tDCS, are receiving increasing attention. The knowledge of molecular mechanisms subtending tDCS effects is of pivotal importance for a more rationale use of this technique in clinical settings. Although we are still far from having a clear picture, recent literature on human and animal studies has pointed to the involvement of synaptic plasticity mechanisms in mediating tDCS effects on long-term memory. Here we review these studies focusing on the neurotrophin "brain-derived neurotrophic factor" (BDNF) as critical tDCS effector. |
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| AbstractList | In the recent years numerous studies have provided encouraging results supporting the use of transcranial direct current stimulation (tDCS) as non-invasive brain stimulation technique to improve motor and cognitive functions in patients suffering from neurological and neuropsychiatric disorders as well as in healthy subjects. Among the multiple effects elicited by tDCS on cognitive functions, experimental evidence and clinical findings have highlighted the beneficial impact on long-term memory. Memory deficits occur during physiological aging as well as in neurological and neurodegenerative disorders, including Alzheimer’s disease. In this scenario, non-invasive techniques for memory enhancement, such as tDCS, are receiving increasing attention. The knowledge of molecular mechanisms subtending tDCS effects is of pivotal importance for a more rationale use of this technique in clinical settings. Although we are still far from having a clear picture, recent literature on human and animal studies has pointed to the involvement of synaptic plasticity mechanisms in mediating tDCS effects on long-term memory. Here we review these studies focusing on the neurotrophin BDNF as critical tDCS effector. In the recent years numerous studies have provided encouraging results supporting the use of transcranial direct current stimulation (tDCS) as non-invasive brain stimulation technique to improve motor and cognitive functions in patients suffering from neurological and neuropsychiatric disorders as well as in healthy subjects. Among the multiple effects elicited by tDCS on cognitive functions, experimental evidence and clinical findings have highlighted the beneficial impact on long-term memory. Memory deficits occur during physiological aging as well as in neurological and neurodegenerative disorders, including Alzheimer's disease (AD). In this scenario, non-invasive techniques for memory enhancement, such as tDCS, are receiving increasing attention. The knowledge of molecular mechanisms subtending tDCS effects is of pivotal importance for a more rationale use of this technique in clinical settings. Although we are still far from having a clear picture, recent literature on human and animal studies has pointed to the involvement of synaptic plasticity mechanisms in mediating tDCS effects on long-term memory. Here we review these studies focusing on the neurotrophin "brain-derived neurotrophic factor" (BDNF) as critical tDCS effector.In the recent years numerous studies have provided encouraging results supporting the use of transcranial direct current stimulation (tDCS) as non-invasive brain stimulation technique to improve motor and cognitive functions in patients suffering from neurological and neuropsychiatric disorders as well as in healthy subjects. Among the multiple effects elicited by tDCS on cognitive functions, experimental evidence and clinical findings have highlighted the beneficial impact on long-term memory. Memory deficits occur during physiological aging as well as in neurological and neurodegenerative disorders, including Alzheimer's disease (AD). In this scenario, non-invasive techniques for memory enhancement, such as tDCS, are receiving increasing attention. The knowledge of molecular mechanisms subtending tDCS effects is of pivotal importance for a more rationale use of this technique in clinical settings. Although we are still far from having a clear picture, recent literature on human and animal studies has pointed to the involvement of synaptic plasticity mechanisms in mediating tDCS effects on long-term memory. Here we review these studies focusing on the neurotrophin "brain-derived neurotrophic factor" (BDNF) as critical tDCS effector. In the recent years numerous studies have provided encouraging results supporting the use of transcranial direct current stimulation (tDCS) as non-invasive brain stimulation technique to improve motor and cognitive functions in patients suffering from neurological and neuropsychiatric disorders as well as in healthy subjects. Among the multiple effects elicited by tDCS on cognitive functions, experimental evidence and clinical findings have highlighted the beneficial impact on long-term memory. Memory deficits occur during physiological aging as well as in neurological and neurodegenerative disorders, including Alzheimer’s disease (AD). In this scenario, non-invasive techniques for memory enhancement, such as tDCS, are receiving increasing attention. The knowledge of molecular mechanisms subtending tDCS effects is of pivotal importance for a more rationale use of this technique in clinical settings. Although we are still far from having a clear picture, recent literature on human and animal studies has pointed to the involvement of synaptic plasticity mechanisms in mediating tDCS effects on long-term memory. Here we review these studies focusing on the neurotrophin “brain-derived neurotrophic factor” (BDNF) as critical tDCS effector. |
| Author | Cocco, Sara Grassi, Claudio Podda, Maria V. |
| AuthorAffiliation | 2 Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome , Italy 1 Institute of Human Physiology, Università Cattolica del Sacro Cuore , Rome , Italy |
| AuthorAffiliation_xml | – name: 1 Institute of Human Physiology, Università Cattolica del Sacro Cuore , Rome , Italy – name: 2 Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome , Italy |
| Author_xml | – sequence: 1 givenname: Sara surname: Cocco fullname: Cocco, Sara – sequence: 2 givenname: Maria V. surname: Podda fullname: Podda, Maria V. – sequence: 3 givenname: Claudio surname: Grassi fullname: Grassi, Claudio |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29997473$$D View this record in MEDLINE/PubMed |
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| Keywords | memory synaptic plasticity BDNF tDCS epigenetics personalized medicine |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Edited by: Ioan Opris, University of Miami, United States This article was submitted to Neural Technology, a section of the journal Frontiers in Neuroscience Reviewed by: Filippo Brighina, Università degli Studi di Palermo, Italy; Gianluca Esposito, Nanyang Technological University, Singapore |
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| Title | Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation |
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