PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis - Mukhopadhyay, Partha; Horváth, Béla; Rajesh, Mohanraj; Varga, Zoltán V.; Gariani, Karim; Ryu, Dongryeol; Cao, Zongxian; Holovac, Eileen; Park, Ogyi; Zhou, Zhou; Xu, Ming-Jiang; Wang, Wei; et al. (Journal of hepatology, 2017)
Keywords: Alcoholic beverages; Alcohols; Animal models; Animals; Cancer; Cell activation; Choline; Clonal deletion; Cystic fibrosis; Diet, High-Fat - adverse effects; Disease Models, Animal; Fatty Acids - metabolism; Fatty liver; Fatty Liver, Alcoholic - genetics; Fatty Liver, Alcoholic - metabolism; Fatty Liver, Alcoholic - prevention & control; Fibrosis; Gastroenterology and Hepatology; Hepatitis; High fat diet; Humans; Inflammation; Kupffer cells; Kupffer Cells - drug effects; Kupffer Cells - metabolism; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver diseases; Male; Metabolism; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial DNA; NAD; NAD - metabolism; NASH; Nitrosative Stress - drug effects; Non-alcoholic Fatty Liver Disease - genetics; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - prevention & control; Nutrient deficiency; Oxidative stress; Oxidative Stress - drug effects; Phenanthrenes - pharmacology; Phthalazines - pharmacology; Piperazines - pharmacology; Poly (ADP-Ribose) Polymerase-1 - deficiency; Poly (ADP-Ribose) Polymerase-1 - genetics; Poly(ADP-ribose); Poly(ADP-ribose) polymerase; Poly(ADP-ribose) Polymerase 1; Poly(ADP-ribose) Polymerase Inhibitors - pharmacology; Polymerase chain reaction; Quinolines - pharmacology; Reactive oxygen species; Ribose; SIRT1 protein; Sirtuin 1 - metabolism; Sirtuins; NAD; Oxidative stress; Mitochondria; Reactive oxygen species; Fatty liver; Kupffer cells; Inflammation; NASH; Alcohols; NAD(+)