Thioester-containing protein TEP15 promotes malaria parasite development in mosquitoes through negative regulation of melanization

• Published in: Parasites & vectors Vol. 18; no. 1; p. 124
• Main Authors: Qin, Xin, Li, Jianyong, Zhu, Feng, Zhang, Jian
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.04.2025; BioMed Central; BMC
• Subjects: Animals; Anopheles - genetics; Anopheles - immunology; Anopheles - parasitology; Anopheles stephensi; AsTEP15; Cellular proteins; family; Female; females; functional diversity; gene expression regulation; genes; Genetic aspects; Genetic regulation; Health aspects; Host-parasite relationships; Immune response; Immunity, Innate; innate immunity; Insect Proteins - genetics; Insect Proteins - immunology; Insect Proteins - metabolism; Malaria; Malaria - parasitology; Malaria - transmission; Melanins - metabolism; Melanization; Mice; Mosquito Vectors - genetics; Mosquito Vectors - immunology; Mosquito Vectors - parasitology; oocysts; parasites; Plasmodium; Plasmodium yoelii; Plasmodium yoelii - growth & development; Plasmodium yoelii - immunology; quantitative polymerase chain reaction; Risk factors; sporozoites; t-test; Thioester-containing protein; Western blotting; China; Plasmodium; Anopheles stephensi; AsTEP15; Melanization; Thioester-containing protein

Thioester-containing proteins (TEPs) serve as crucial effectors and regulatory components within the innate immune system of mosquitoes. Despite their significance, the mechanisms by which TEPs exert negative regulation on the immune response in mosquitoes remain inadequately understood. This study...