The Success and Failure of the Schwann Cell Response to Nerve Injury

• Published in: Frontiers in cellular neuroscience Vol. 13; p. 33
• Main Authors: Jessen, Kristjan R., Mirsky, Rhona
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 11.02.2019; Frontiers Media S.A
• Subjects: c-Jun; Cell adhesion & migration; Fibroblasts; Genotype & phenotype; Myelin; nerve injury; Neuroscience; Neurosciences; Peripheral nerves; Phenotypes; PNS; Proteins; re-programming; Regeneration; repair cell; Schwann cells; Steam; Transcription factors; c-Jun; PNS; Schwann cell; regeneration; nerve injury; re-programming; repair cell

The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin) and myelin phenotypes, which are specialized to meet the needs of small and large diameter axons, and differ markedly from each other. It also enables Schwann cells initially to mount a strikingly adaptive respons...