Cirsium japonicum Flavones Enhance Adipocyte Differentiation and Glucose Uptake in 3T3-L1 Cells

• Published in: Biological & pharmaceutical bulletin Vol. 35; no. 6; pp. 855 - 860
• Main Authors: Liao, Zhiyong, Wu, Zhihua, Wu, Mingjiang
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 2012; Japan Science and Technology Agency
• Subjects: 3T3-L1 Cells; adipocyte differentiation; Adipocytes - cytology; Adipocytes - drug effects; Adipogenesis - drug effects; adiponectin; Adiponectin - genetics; Animals; Cell Differentiation - drug effects; Chromones - pharmacology; Cirsium; Cirsium japonicum; flavone; Flavones - pharmacology; Glucose - metabolism; glucose transporter 4; Glucose Transporter Type 4 - genetics; Mice; peroxisome proliferator-activated receptor γ; PPAR gamma - genetics; PPAR gamma - metabolism

Cirsium japonicum flavones have been demonstrated to possess anti-diabetic effects in diabetic rats, but the functional mechanism remains unknown. The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) plays an important role in glucose and lipid homeostasis. In this study, we rep...