The effect of glucocorticoids on tendon cell viability in human tendon explants

• Published in: Acta orthopaedica Vol. 80; no. 3; pp. 363 - 367
• Main Authors: Wan Nar Wong, Margaret, Lui, Wai Ting, Chuen Fu, Sai, Man Lee, Kwong
• Format: Journal Article
• Language: English
• Published: Basingstoke Informa UK Ltd 2009; Taylor & Francis; Informa Healthcare
• Subjects: Biological and medical sciences; Cell Survival - drug effects; Cells, Cultured; Dexamethasone - pharmacology; Diseases of the osteoarticular system; Glucocorticoids - pharmacology; Humans; Medical sciences; Tendons - cytology; Tendons - drug effects; Tendons - metabolism; Triamcinolone - pharmacology; Human; Explant; Glucocorticoid; Viability; Orthopedics; Tendon

Background and purpose Previous studies on the culture of human tenocytes have shown that dexamethasone and triamcino-lone reduce cell viability, suppress cell proliferation, and reduce collagen synthesis. However, such cell cultures lack the extracellular matrix and three-dimensional structure of n...