Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites

• Published in: Neurobiology of aging Vol. 34; no. 5; pp. 1504 - 1515
• Main Authors: Jiang, Peizhou, Gan, Ming, Ebrahim, Abdul Shukkur, Castanedes-Casey, Monica, Dickson, Dennis W., Yen, Shu-Hui C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2013
• Subjects: Alpha-synuclein; alpha-Synuclein - chemistry; alpha-Synuclein - metabolism; AMPK; Animals; Cells, Cultured; Dimerization; Enzyme Activation; Humans; Internal Medicine; Lactate; Mice; Neurites - metabolism; Neurites - pathology; Neurology; Parkinson's disease; Protein Kinases - metabolism; Up-Regulation; AMPK; Parkinson's disease; Lactate; Alpha-synuclein

Neuronal inclusions of α-synuclein (α-syn), termed Lewy bodies, are a hallmark of Parkinson disease (PD). Increased α-syn levels can occur in brains of aging human and neurotoxin-treated mice. Because previous studies have shown increased brain lactate levels in aging brains, in PD affected subjects...