Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease

• Published in: Neurobiology of aging Vol. 89; pp. 108 - 117
• Main Authors: Tadayon, Ehsan, Pascual-Leone, Alvaro, Press, Daniel, Santarnecchi, Emiliano
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2020
• Subjects: alpha-Synuclein - cerebrospinal fluid; Alzheimer Disease - diagnosis; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Alzheimer's disease; Amyloid beta-Peptides - cerebrospinal fluid; Biomarkers - cerebrospinal fluid; Choroid plexus; Choroid Plexus - diagnostic imaging; Choroid Plexus - pathology; Choroid Plexus - physiopathology; CSF clearance; CSF proteins; Organ Size; Parkinson Disease - diagnosis; Parkinson Disease - diagnostic imaging; Parkinson Disease - pathology; Parkinson Disease - physiopathology; Parkinson's disease; Positron-Emission Tomography; tau Proteins; Choroid plexus; Parkinson's disease; CSF clearance; Alzheimer's disease; CSF proteins

The choroid plexus (ChP) is a major source of cerebrospinal fluid (CSF) production, with a direct and indirect role in protein clearance, and pathogenesis of Alzheimer's disease (AD). Here, we tested the link between the ChP volume and levels of CSF proteins in 2 data sets of (i) healthy contro...