Pro-apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells

• Published in: International journal of oncology Vol. 46; no. 4; pp. 1629 - 1636
• Main Authors: HARATI, KAMRAN, SLODNIK, PAWEL, CHROMIK, ANSGAR MICHAEL, BEHR, BJÖRN, GOERTZ, OLE, HIRSCH, TOBIAS, KAPALSCHINSKI, NICOLAI, KLEIN-HITPASS, LUDGER, KOLBENSCHLAG, JONAS, UHL, WALDEMAR, LEHNHARDT, MARCUS, DAIGELER, ADRIEN
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.04.2015; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Adult; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacokinetics; Apoptosis; Apoptosis - drug effects; cancer; Cancer therapies; Care and treatment; catechin; Catechin - pharmacology; Cell Line, Tumor; Cell Proliferation - drug effects; Chemotherapy; CTNNA1; Disease; Drug Synergism; epicatechin; Female; Fibrosarcoma; Fibrosarcoma - drug therapy; Fibrosarcoma - genetics; Fibrosarcoma - pathology; Flavonoids; Flavonoids - administration & dosage; Flavonoids - pharmacokinetics; fluorescence-activated cell sorting; FN1; gene expression; Gene Expression Regulation, Neoplastic - drug effects; Gene Expression Regulation, Neoplastic - genetics; Genes; Health aspects; Humans; ITGB1; JAK1; Kinases; LAMC1; Male; Metastasis; Molecular Sequence Data; necrosis; Phosphatase; pycnogenol; Quercetin - analogs & derivatives; Quercetin - pharmacology; Response rates; RHOA; Sarcoma; Signal Transduction - drug effects; soft tissue sarcoma; taxifolin; Young Adult; United States > US; Europe

Complete surgical resection with clear margins remains the mainstay of therapy for localised fibrosarcomas. Nevertheless, metastatic fibrosarcomas still represent a therapeutic dilemma. Commonly used chemotherapeutic agents like doxorubicin have proven to be effective in <30% of all cases of diss...