NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies

• Published in: Frontiers in cellular neuroscience Vol. 11; p. 63
• Main Authors: Song, Limin, Pei, Lei, Yao, Shanglong, Wu, Yan, Shang, You
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 09.03.2017; Frontiers Media S.A
• Subjects: Adenosine triphosphate; Anesthesiology; astrocytes; Brain injury; Caspase; Caspase-1; Cell death; Central nervous system; Critical care; Cytokines; Endogenous stimuli; Hospitals; IL-1β; inflammasome; Inflammasomes; Inflammation; Interleukin 1; Interleukin 18; Kinases; Leucine; Medicine; microglia; Neurobiology; Neurodegenerative diseases; neuroinflammation; Neurological diseases; Neuroscience; Neurosciences; NLRP3; Oligomerization; Oxidative stress; Protein folding; Proteins; Pyrin protein; Spinal cord injuries; Traumatic brain injury; Tumor necrosis factor-TNF; China; neuroinflammation; IL-18; inflammasome; NLRP3; astrocytes; IL-1β; microglia

Neuroinflammation has been identified as a causative factor of multiple neurological diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3 (NLRP3) inflammasome, a subcellular multiprotein complex that is abundantly expressed in the central nervo...