Dissociation of Frontal and Medial Temporal Lobe Activity in Maintenance and Binding of Sequentially Presented Paired Associates

• Published in: Journal of cognitive neuroscience Vol. 21; no. 7; pp. 1244 - 1254
• Main Authors: Hales, Jena B., Israel, Sarah L., Swann, Nicole C., Brewer, James B.
• Format: Journal Article
• Language: English
• Published: One Rogers Street, Cambridge, MA 02142-1209, USA MIT Press 01.07.2009; MIT Press Journals, The
• Subjects: Analysis of Variance; Brain; Brain Mapping; Cognition & reasoning; Female; Frontal Lobe - blood supply; Frontal Lobe - physiology; Functional Laterality - physiology; Humans; Image Processing, Computer-Assisted - methods; Magnetic Resonance Imaging; Male; Memory; Neurosciences; NMR; Nuclear magnetic resonance; Oxygen - blood; Paired-Associate Learning - physiology; Pattern Recognition, Visual - physiology; Photic Stimulation - methods; Reaction Time - physiology; Recognition (Psychology) - physiology; Studies; Temporal Lobe - blood supply; Temporal Lobe - physiology; Time Factors; Young Adult

Substructures of the prefrontal cortex (PFC) and the medial-temporal lobe are critical for associating objects presented over time. Previous studies showing frontal and medial-temporal involvement in associative encoding have not addressed the response specificity of these regions to different aspec...