Myofibroblast differentiation and survival in fibrotic disease

• Published in: Expert reviews in molecular medicine Vol. 13; p. e27
• Main Authors: Kis, Kornelia, Liu, Xiaoqiu, Hagood, James S.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 23.08.2011
• Subjects: Animals; Cell Differentiation; Humans; Myofibroblasts - pathology; Pulmonary Fibrosis - pathology

During wound healing, contractile fibroblasts called myofibroblasts regulate the formation and contraction of granulation tissue; however, pathological and persistent myofibroblast activation, which occurs in hypertrophic scars or tissue fibrosis, results in a loss of function. Many reviews outline...