Acquisition and Adaptation of Ultra-small Parasitic Reduced Genome Bacteria to Mammalian Hosts

• Published in: Cell reports (Cambridge) Vol. 32; no. 3; p. 107939
• Main Authors: McLean, Jeffrey S., Bor, Batbileg, Kerns, Kristopher A., Liu, Quanhui, To, Thao T., Solden, Lindsey, Hendrickson, Erik L., Wrighton, Kelly, Shi, Wenyuan, He, Xuesong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.07.2020; Elsevier
• Subjects: Acetobacteraceae - genetics; Adaptation, Physiological - genetics; Animals; Bacterial Secretion Systems - genetics; BASIC BIOLOGICAL SCIENCES; Biodiversity; candidate phyla radiation; Environmental Microbiology; epibiont; Genome Size; Genome, Bacterial; Host-Pathogen Interactions - genetics; Humans; Mammals - microbiology; metagenome; micrbiome; Mouth - microbiology; Nanosynbacter; oral bacteria; Phylogeny; Phylogeography; Principal Component Analysis; Saccharibacteria; TM7; ultra-small bacteria; ultra-small bacteria; epibiont; micrbiome; metagenome; Nanosynbacter; candidate phyla radiation; oral bacteria; Saccharibacteria; TM7

The first cultivated representative of the enigmatic phylum Saccharibacteria (formerly TM7) was isolated from humans and revealed an ultra-small cell size (200–300 nm), a reduced genome with limited biosynthetic capabilities, and a unique parasitic lifestyle. TM7x was the only cultivated member of t...