Idiotype vaccination in patients with myeloma reduced circulating myeloma cells (CMC)

• Published in: Annals of oncology Vol. 19; no. 6; pp. 1172 - 1179
• Main Authors: Abdalla, A.O., Kokhaei, P., Hansson, L., Mellstedt, H., Österborg, A.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.06.2008; Oxford University Press; Oxford Publishing Limited (England)
• Subjects: Adjuvants, Immunologic - administration & dosage; Aged; Aged, 80 and over; Antineoplastic agents; Biological and medical sciences; Cancer Vaccines - immunology; Cancer Vaccines - therapeutic use; circulating myeloma cells; Female; Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage; Hematologic and hematopoietic diseases; Humans; idiotype vaccination; Immunodeficiencies. Immunoglobulinopathies; Immunoglobulin Idiotypes - immunology; Immunoglobulin Idiotypes - therapeutic use; Immunoglobulinopathies; Immunopathology; Interleukin-12 - administration & dosage; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Medicin och hälsovetenskap; Middle Aged; multiple myeloma; Multiple Myeloma - drug therapy; Multiple Myeloma - immunology; Neoplastic Cells, Circulating - drug effects; Pharmacology. Drug treatments; Vaccination; circulating myeloma cells; idiotype vaccination; multiple myeloma; Human; Immunopathology; Vaccination; B cell neoplasm; Malignant hemopathy; Lymphoid neoplasm; Myeloma; In vitro; Prevention; Immunoglobulinopathy; Lymphoproliferative syndrome; Cancer; Idiotype

Circulating myeloma cells (CMC), exhibiting the same immunoglobulin heavy-chain gene rearrangements as the plasma cells, are part of the myeloma clone. In this study, we evaluated the effect of idiotype (Id) vaccination on CMC. Eleven patients were immunized with the autologous Id in combinations wi...