Higher Esophageal Symptom Burden in Obese Subjects Results From Increased Esophageal Acid Exposure and Not From Dysmotility

• Published in: Clinical gastroenterology and hepatology Vol. 18; no. 8; pp. 1719 - 1726
• Main Authors: Rogers, Benjamin D., Patel, Amit, Wang, Dan, Sayuk, Gregory S., Gyawali, C. Prakash
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2020
• Subjects: Ambulatory Reflux Monitoring; Esophageal pH Monitoring; Gastroenterology and Hepatology; Gastroesophageal Reflux - complications; GERD; High-Resolution Manometry; Humans; Manometry; Obesity - complications; Retrospective Studies; Symptom Association Probability; HRM; SAP; CCv3.0; GSS; PPI; EGJ; AET; GERD; Symptom Association Probability; Ambulatory Reflux Monitoring; DSI; EMD; High-Resolution Manometry; BMI; global symptom severity; Chicago Classification version 3.0; body mass index; esophageal motor disorders; esophagogastric junction; proton pump inhibitor; dominant symptom intensity; acid exposure time

Esophageal motor disorders (EMD) and pathologic reflux are often identified in obese individuals, but it is not clear how obesity contributes to these symptoms. We examined the relationships among symptom burden, EMD, acid exposure time (AET), symptom association probability, and body mass index (BM...