Sparse Simultaneous Signal Detection for Identifying Genetically Controlled Disease Genes

• Published in: Journal of the American Statistical Association Vol. 112; no. 519; pp. 1032 - 1046
• Main Authors: Zhao, Sihai Dave, Cai, T. Tony, Cappola, Thomas P., Margulies, Kenneth B., Li, Hongzhe
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 03.07.2017; Taylor & Francis Group,LLC
• Subjects: Applications and Case Studies; death; eQTL; equations; etiology; gene expression regulation; genes; genetic variation; genome-wide association study; genomics; GWAS; heart failure; Higher criticism; Integrative genomics; linkage disequilibrium; quantitative trait loci; risk; single nucleotide polymorphism; statistical analysis; United States; United States; GWAS; eQTL; Higher criticism; Integrative genomics

Genome-wide association studies (GWAS) and differential expression analyses have had limited success in finding genes that cause complex diseases such as heart failure (HF), a leading cause of death in the United States. This article proposes a new statistical approach that integrates GWAS and expre...