I-BAR domain proteins: linking actin and plasma membrane dynamics

• Published in: Current opinion in cell biology Vol. 23; no. 1; pp. 14 - 21
• Main Authors: Zhao, Hongxia, Pykäläinen, Anette, Lappalainen, Pekka
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2011
• Subjects: actin; Actins - metabolism; Animals; Cell Membrane - metabolism; deformation; endocytosis; Humans; Internal Medicine; Membrane Proteins - chemistry; Membrane Proteins - metabolism; morphogenesis; plasma membrane; polymerization; Protein Structure, Tertiary; protein-protein interactions; pseudopodia

Dynamic plasma membrane rearrangements occur during many cellular processes including endocytosis, morphogenesis, and migration. Actin polymerization together with proteins that directly deform membranes, such as the BAR superfamily proteins, is essential for generation of membrane invaginations dur...