Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

• Published in: Frontiers in cellular neuroscience Vol. 9; p. 392
• Main Authors: Kelly, John R., Kennedy, Paul J., Cryan, John F., Dinan, Timothy G., Clarke, Gerard, Hyland, Niall P.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 14.10.2015; Frontiers Media S.A
• Subjects: Central nervous system; Depression; Digestive system; E coli; Gastrointestinal tract; Gut Microbiota; Gut–brain axis; Influence; intestinal barrier; Intestinal microflora; Intestine; Irritable bowel syndrome; Mental disorders; Microbiomes; Microbiota; Nervous system; Neuroscience; Permeability; Probiotics; Proteins; psychobiotics; Signal transduction; University colleges; Ireland; psychobiotics; depression; intestinal barrier; gut microbiota; gut-brain axis; probiotics

The emerging links between our gut microbiome and the central nervous system (CNS) are regarded as a paradigm shift in neuroscience with possible implications for not only understanding the pathophysiology of stress-related psychiatric disorders, but also their treatment. Thus the gut microbiome and...