Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions

• Published in: Frontiers in cellular neuroscience Vol. 13; p. 87
• Main Authors: Fogaça, Manoela V., Duman, Ronald S.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 12.03.2019; Frontiers Media S.A
• Subjects: Antidepressants; Brain architecture; Clonal deletion; depression; Drug development; Drugs; Functional anatomy; GABA; Glutamatergic transmission; Hypotheses; Interneurons; Mental depression; Neuropeptides; Neuroscience; Neurosciences; Neurotransmission; Parvalbumin; Prefrontal cortex; Proteins; Psychiatry; Receptor mechanisms; Somatostatin; Stress; Synaptic transmission; Therapeutic applications; γ-Aminobutyric acid A receptors; γ-Aminobutyric acid B receptors; γ-Aminobutyric acid receptors; United States > US; stress; ketamine; parvalbumin; prefrontal cortex; somatostatin; GABA; depression

Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be precipitated by exposure to chronic stress. For decades, the monoaminergic deficit hypothesis of depression pro...