Biphasic Regulation of Mammary Epithelial Resistance by Serotonin through Activation of Multiple Pathways

• Published in: The Journal of biological chemistry Vol. 283; no. 45; pp. 30901 - 30910
• Main Authors: Pai, Vaibhav P., Horseman, Nelson D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.11.2008; American Society for Biochemistry and Molecular Biology
• Subjects: Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases - metabolism; Dose-Response Relationship, Drug; Electric Impedance; Female; Humans; Mammary Glands, Human - cytology; Mammary Glands, Human - metabolism; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - physiology; Mechanisms of Signal Transduction; p38 Mitogen-Activated Protein Kinases - metabolism; Receptors, Serotonin - metabolism; Serotonin - pharmacology; Tight Junctions - metabolism

Mammary gland homeostasis and the lactation-to-involution switch are regulated by serotonin (5-hydroxytryptamine (5-HT)). Mammary epithelial tight junctions are physiological targets of 5-HT, and their disruption marks an early stage of mammary gland involution. In these studies, we have identified...