Screening of mammalian DNA polymerase and topoisomerase inhibitors from Garcinia mangostana L. and analysis of human cancer cell proliferation and apoptosis - ONODERA, TAKEFUMI; TAKENAKA, YUKIKO; KOZAKI, SACHIKO; TANAHASHI, TAKAO; MIZUSHINA, YOSHIYUKI (International journal of oncology, 2016)
Keywords: Analysis; Animals; anticancer; Antineoplastic Agents - chemistry; Apoptosis; Cancer; Caspase 3 - metabolism; Cattle; Cell Cycle; Cell division; Cell growth; Cell Proliferation; Cervical cancer; Chromatography; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA polymerase inhibition; DNA polymerases; DNA topoisomerase inhibition; DNA, Single-Stranded - chemistry; DNA-Directed DNA Polymerase - metabolism; E coli; Enzymes; Fruits; Garcinia mangostana - chemistry; Genetic aspects; HeLa Cells; Humans; Indoles - chemistry; Inhibitory Concentration 50; Kinases; mangosteen; Medical screening; Metabolism; Neoplasms - drug therapy; Neoplasms - metabolism; Nucleic Acid Synthesis Inhibitors - chemistry; Protein binding; Rats; RNA polymerase; Topoisomerase Inhibitors - chemistry; Xanthones - chemistry; β-mangostin; Japan