Individual differences in in vitro and in vivo metabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5

• Published in: Human psychopharmacology Vol. 31; no. 2; pp. 93 - 102
• Main Authors: Okubo, Maho, Morita, Shoko, Murayama, Norie, Akimoto, Youichi, Goto, Akiko, Yamazaki, Hiroshi
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.03.2016; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Antipsychotic Agents - pharmacokinetics; Antipsychotic Agents - therapeutic use; Asian Continental Ancestry Group - genetics; clearance; CYP2D6; CYP3A5; Cytochrome P-450 CYP1A2 - metabolism; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 - metabolism; Cytochrome P-450 CYP3A - genetics; Cytochrome P-450 CYP3A - metabolism; Dose-Response Relationship, Drug; Female; Genotyping Techniques; Humans; Japan; Japanese; Male; Microsomes, Liver - drug effects; Microsomes, Liver - enzymology; Middle Aged; paliperidone; Recombinant Proteins - metabolism; risperidone; Risperidone - pharmacokinetics; Risperidone - therapeutic use; Smoking - genetics; Smoking - metabolism; Young Adult; clearance; paliperidone; CYP2D6; CYP3A5; Japanese; risperidone

Objective There are conflicting reports regarding the effects of cytochrome P450 (P450, CYP) genotypes on the plasma concentrations of risperidone and its pharmacologically active metabolite, 9‐hydroxyrisperidone (paliperidone), in clinical patients. The aim of this study was to investigate individu...