Individual differences in in vitro and in vivo metabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5 - Okubo, Maho; Morita, Shoko; Murayama, Norie; Akimoto, Youichi; Goto, Akiko; Yamazaki, Hiroshi (Human psychopharmacology, 2016)
Keywords: Adult; Aged; Antipsychotic Agents - pharmacokinetics; Antipsychotic Agents - therapeutic use; Asian Continental Ancestry Group - genetics; clearance; CYP2D6; CYP3A5; Cytochrome P-450 CYP1A2 - metabolism; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 - metabolism; Cytochrome P-450 CYP3A - genetics; Cytochrome P-450 CYP3A - metabolism; Dose-Response Relationship, Drug; Female; Genotyping Techniques; Humans; Japan; Japanese; Male; Microsomes, Liver - drug effects; Microsomes, Liver - enzymology; Middle Aged; paliperidone; Recombinant Proteins - metabolism; risperidone; Risperidone - pharmacokinetics; Risperidone - therapeutic use; Smoking - genetics; Smoking - metabolism; Young Adult; clearance; paliperidone; CYP2D6; CYP3A5; Japanese; risperidone