Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3

• Published in: Human psychopharmacology Vol. 31; no. 2; pp. 83 - 92
• Main Authors: Okubo, Maho, Narita, Momoko, Murayama, Norie, Akimoto, Youichi, Goto, Akiko, Yamazaki, Hiroshi
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.03.2016; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Antipsychotic Agents - chemistry; Antipsychotic Agents - pharmacokinetics; Antipsychotic Agents - therapeutic use; Asian Continental Ancestry Group - genetics; Benzodiazepines - chemistry; Benzodiazepines - pharmacokinetics; Benzodiazepines - therapeutic use; clearance; CYP1A2; CYP2D6; Cytochrome P-450 CYP1A2 - metabolism; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 - metabolism; Female; FMO3; Genotyping Techniques; Humans; Japan; Japanese; Male; Microsomes, Liver - drug effects; Microsomes, Liver - enzymology; Middle Aged; Molecular Structure; olanzapine; Oxygenases - genetics; Oxygenases - metabolism; Recombinant Proteins - metabolism; Smoking - genetics; Smoking - metabolism; olanzapine; clearance; FMO3; CYP2D6; Japanese; CYP1A2

Objective The antipsychotic olanzapine is reportedly metabolized by inducible human cytochrome P450 (CYP) 1A2 and variable copy‐number CYP2D6 and polymorphic flavin‐containing monooxygenase 3 (FMO3) in different pathways. We investigated individual differences in the metabolite formation and clearan...