Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3 - Okubo, Maho; Narita, Momoko; Murayama, Norie; Akimoto, Youichi; Goto, Akiko; Yamazaki, Hiroshi (Human psychopharmacology, 2016)
Keywords: Adult; Aged; Antipsychotic Agents - chemistry; Antipsychotic Agents - pharmacokinetics; Antipsychotic Agents - therapeutic use; Asian Continental Ancestry Group - genetics; Benzodiazepines - chemistry; Benzodiazepines - pharmacokinetics; Benzodiazepines - therapeutic use; clearance; CYP1A2; CYP2D6; Cytochrome P-450 CYP1A2 - metabolism; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 - metabolism; Female; FMO3; Genotyping Techniques; Humans; Japan; Japanese; Male; Microsomes, Liver - drug effects; Microsomes, Liver - enzymology; Middle Aged; Molecular Structure; olanzapine; Oxygenases - genetics; Oxygenases - metabolism; Recombinant Proteins - metabolism; Smoking - genetics; Smoking - metabolism; olanzapine; clearance; FMO3; CYP2D6; Japanese; CYP1A2