Molecular Imaging Visualizes Recruitment of Inflammatory Monocytes and Macrophages to the Injured Heart

• Published in: Circulation research Vol. 124; no. 6; pp. 881 - 890
• Main Authors: Heo, Gyu Seong, Kopecky, Benjamin, Sultan, Deborah, Ou, Monica, Feng, Guoshuai, Bajpai, Geetika, Zhang, Xiaohui, Luehmann, Hannah, Detering, Lisa, Su, Yi, Leuschner, Florian, Combadière, Christophe, Kreisel, Daniel, Gropler, Robert J., Brody, Steven L., Liu, Yongjian, Lavine, Kory J.
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 15.03.2019; American Heart Association
• Subjects: Animals; Cell Movement; Heart - diagnostic imaging; Humans; Life Sciences; Macrophages - physiology; Mice; Mice, Inbred C57BL; Molecular Imaging; Monocytes - physiology; Myocardial Reperfusion Injury - pathology; Myocytes, Cardiac - pathology; Positron-Emission Tomography; Receptors, CCR2 - analysis; monocytes; macrophages; molecular imaging; positron emission tomography; myocardial infarction

RATIONALE:Paradigm shifting studies have revealed that the heart contains functionally diverse populations of macrophages derived from distinct embryonic and adult hematopoietic progenitors. Under steady-state conditions, the heart is largely populated by CCR2− (C-C chemokine receptor type 2) macrop...