An Albumin‐Photosensitizer Supramolecular Assembly with Type I ROS‐Induced Multifaceted Tumor Cell Deaths for Photodynamic Immunotherapy

• Published in: Advanced science Vol. 12; no. 9; pp. e2410405 - n/a
• Main Authors: Zhang, Jingtian, Jiao, Di, Qi, Xinwen, Zhang, Yufan, Liu, Xiaoang, Pan, Tengwu, Gao, Heqi, Liu, Zhaoyun, Ding, Dan, Feng, Guangxue
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.03.2025; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Apoptosis - drug effects; Cell death; Cell Line, Tumor; Cytokines; Ferroptosis; Humans; Hydrogen; Hypoxia; immunogenic cell death; Immunotherapy; Immunotherapy - methods; Mice; Nanoparticles; Neoplasms - drug therapy; Oxidative stress; Photochemotherapy - methods; Photosensitizing Agents - pharmacology; Polyethylene glycol; programmed cell death; Proteins; pyroptosis; Reactive Oxygen Species - metabolism; Serum Albumin, Bovine; Tumors; Type I photodynamic therapy; pyroptosis; ferroptosis; programmed cell death; Type I photodynamic therapy; immunogenic cell death

Photodynamic therapy holds great potentials in cancer treatment, yet its effectiveness in hypoxic solid tumor is limited by the oxygen‐dependence and insufficient oxidative potential of conventional type II reactive oxygen species (ROS). Herein, the study reports a supramolecular photosensitizer, BS...