Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase - Salari, Saman; Lee, Hiu‐Fung; Tsantrizos, Youla S.; Park, Jaeok (FEBS open bio, 2024)
Keywords: Allosteric properties; Allosteric Regulation - drug effects; Alzheimer's disease; Cancer therapies; Chromatography; Dehydrogenases; Enzyme inhibitors; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Enzyme Kinetics; Enzymes; farnesyl pyrophosphate; Farnesyl pyrophosphate synthase; Feedback; Feedback inhibition; Geranyltranstransferase - antagonists & inhibitors; Geranyltranstransferase - metabolism; Humans; isoprenoid synthesis; Kinases; Kinetics; Metabolites; Mevalonate kinase; Mevalonate pathway; Pharmacology; phosphonate compounds; Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors; Phosphotransferases (Alcohol Group Acceptor) - metabolism; Polyisoprenyl Phosphates - metabolism; Sesquiterpenes - chemistry; Sesquiterpenes - metabolism; Sesquiterpenes - pharmacology; Signal transduction; Software; Therapeutic targets; Canada; phosphonate compounds; isoprenoid synthesis; mevalonate pathway; mevalonate kinase; farnesyl pyrophosphate; feedback inhibition