Evaluation of anti-acne properties of phloretin in vitro and in vivo
Synopsis Objective This study aimed to investigate the anti‐acne properties of phloretin in vitro and in vivo. Methods Anti‐microbial activity against Propionibacterium acnes (P. acnes), Propionibacterium granulosum (P. granulosum) and Staphylococcus epidermidis (S. epidermidis) were observed by the...
Saved in:
| Published in | International Journal of Cosmetic Science Vol. 38; no. 1; pp. 85 - 92 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Blackwell Publishing Ltd
01.02.2016
Wiley Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0142-5463 1468-2494 |
| DOI | 10.1111/ics.12263 |
Cover
| Abstract | Synopsis
Objective
This study aimed to investigate the anti‐acne properties of phloretin in vitro and in vivo.
Methods
Anti‐microbial activity against Propionibacterium acnes (P. acnes), Propionibacterium granulosum (P. granulosum) and Staphylococcus epidermidis (S. epidermidis) were observed by the minimum inhibitory concentration (MIC) and disc diffusion methods. The anti‐inflammatory effects were studied in HaCaT cells based on P. acnes‐induced inflammatory mediators, including PGE2 and COX‐2, examined through enzyme‐linked immunosorbent assay (ELISA) and luciferase reporter gene assay. Thirty healthy subjects with whiteheads participated in the clinical study. Comedo counting, and the amount of sebum and porphyrin were measured before treatment and following 4 consecutive weeks of treatment with phloretin.
Results
Phloretin showed anti‐microbial activities against P. acnes, P. granulosum, S. epidermidis with the MIC of 0.5, 0.5 and 0.25 mg mL−1, respectively. P. acnes‐induced activation of the COX‐2 promoter was markedly attenuated by phloretin treatment. Consistent with these results, inhibition of PGE2 production was also observed. In 1‐month, placebo‐controlled trials, phloretin showed clinically and statistically significant reduction of comedo counts and sebum output level. Compared to before treatment, whiteheads, blackheads, papules, sebum output level and amount of sebum and porphyrin were significantly decreased at 4 weeks in the test group.
Conclusions
This study revealed that phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis. In addition, we demonstrated that phloretin attenuates COX‐2 and PGE2 expression during the P. acnes‐induced upregulation of inflammatory signalling. Clinical studies further suggested that treatment with formulations containing phloretin confers anti‐acne benefits. Based on these results, we suggest that phloretin may be introduced as a possible acne‐mitigating agent.
Résumé
Objectif
La présente étude visait à étudier les propriétés anti‐acné de phlorétine in vitro et in vivo.
Méthodes
L'activité anti‐microbienne contre Propionibacterium acnes (P. acnes), Propionibacterium granulosum (P. granulosum), Staphylococcus epidermidis (S. epidermidis) a été étudiée par la method de concentration minimale inhibitrice (CMI) et par des procédés de diffusion de disque. Les effets anti‐inflammatoires ont été étudiés dans des cellules HaCaT, basés sur l'induction des médiateurs inflammatoires, y compris la PGE2 et de la COX‐2, par P. acnes et examinés par ELISA et par le dosage du gène rapporteur de luciférase. Trente sujets sains avec points blancs ont participé à l’étude clinique. Le comptage des comédonset la quantité de sébum et de la porphyrine ont été mesurés avant traitement et après quatre semaines consécutives de traitement avec la phlorétine.
Résultats
La phloretin a montré des activités anti‐microbiennes contre P. acnes, P. granulosum, S. epidermidis avec la CMI de 0,5, 0,5, 0,25 mg mL−1, respectivement. L'activation du promoteur de la COX‐2 induite par P. acnes a été sensiblement atténué par le traitement à la phlorétine. Conformément à ces résultats, l'inhibition de la production de PGE2 a également été observée. En un mois, les essais contrôlés par placebo, ont montré pour la phloretine une réduction cliniquement et statistiquement significative du nombre de comédons et du niveau de production de sebum. Par rapport à avant le traitement, les points blancs et noirs, les papules, le niveau de séborrhée, et la quantité de sébum et de porphyrine étaient significativement diminué à 4 semaines dans le groupe test.
Conclusions
La présente étude a révélé que la phlorétine inhibe la croissance de P. acnes, P. granulosum, et S. epidermidis. De plus, nous avons démontré que la phlorétine atténue l'expresssion de COX‐2 et de PGE2 au cours de l'augmentation de signalisation inflammatoire induite par P. acnes. Des études cliniques ont en outre suggéré que le traitement avec des formulations contenant phloretine confère des avantages anti‐acné. Basé sur ces résultats, nous suggérons que phloretine peut être présenté comme un agent potentiel anti‐acné. |
|---|---|
| AbstractList | This study aimed to investigate the anti-acne properties of phloretin in vitro and in vivo.
Anti-microbial activity against Propionibacterium acnes (P. acnes), Propionibacterium granulosum (P. granulosum) and Staphylococcus epidermidis (S. epidermidis) were observed by the minimum inhibitory concentration (MIC) and disc diffusion methods. The anti-inflammatory effects were studied in HaCaT cells based on P. acnes-induced inflammatory mediators, including PGE2 and COX-2, examined through enzyme-linked immunosorbent assay (ELISA) and luciferase reporter gene assay. Thirty healthy subjects with whiteheads participated in the clinical study. Comedo counting, and the amount of sebum and porphyrin were measured before treatment and following 4 consecutive weeks of treatment with phloretin.
Phloretin showed anti-microbial activities against P. acnes, P. granulosum, S. epidermidis with the MIC of 0.5, 0.5 and 0.25 mg mL(-1) , respectively. P. acnes-induced activation of the COX-2 promoter was markedly attenuated by phloretin treatment. Consistent with these results, inhibition of PGE2 production was also observed. In 1-month, placebo-controlled trials, phloretin showed clinically and statistically significant reduction of comedo counts and sebum output level. Compared to before treatment, whiteheads, blackheads, papules, sebum output level and amount of sebum and porphyrin were significantly decreased at 4 weeks in the test group.
This study revealed that phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis. In addition, we demonstrated that phloretin attenuates COX-2 and PGE2 expression during the P. acnes-induced upregulation of inflammatory signalling. Clinical studies further suggested that treatment with formulations containing phloretin confers anti-acne benefits. Based on these results, we suggest that phloretin may be introduced as a possible acne-mitigating agent. OBJECTIVEThis study aimed to investigate the anti-acne properties of phloretin in vitro and in vivo.METHODSAnti-microbial activity against Propionibacterium acnes (P. acnes), Propionibacterium granulosum (P. granulosum) and Staphylococcus epidermidis (S. epidermidis) were observed by the minimum inhibitory concentration (MIC) and disc diffusion methods. The anti-inflammatory effects were studied in HaCaT cells based on P. acnes-induced inflammatory mediators, including PGE2 and COX-2, examined through enzyme-linked immunosorbent assay (ELISA) and luciferase reporter gene assay. Thirty healthy subjects with whiteheads participated in the clinical study. Comedo counting, and the amount of sebum and porphyrin were measured before treatment and following 4 consecutive weeks of treatment with phloretin.RESULTSPhloretin showed anti-microbial activities against P. acnes, P. granulosum, S. epidermidis with the MIC of 0.5, 0.5 and 0.25 mg mL(-1) , respectively. P. acnes-induced activation of the COX-2 promoter was markedly attenuated by phloretin treatment. Consistent with these results, inhibition of PGE2 production was also observed. In 1-month, placebo-controlled trials, phloretin showed clinically and statistically significant reduction of comedo counts and sebum output level. Compared to before treatment, whiteheads, blackheads, papules, sebum output level and amount of sebum and porphyrin were significantly decreased at 4 weeks in the test group.CONCLUSIONSThis study revealed that phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis. In addition, we demonstrated that phloretin attenuates COX-2 and PGE2 expression during the P. acnes-induced upregulation of inflammatory signalling. Clinical studies further suggested that treatment with formulations containing phloretin confers anti-acne benefits. Based on these results, we suggest that phloretin may be introduced as a possible acne-mitigating agent. Synopsis Objective This study aimed to investigate the anti‐acne properties of phloretin in vitro and in vivo. Methods Anti‐microbial activity against Propionibacterium acnes (P. acnes), Propionibacterium granulosum (P. granulosum) and Staphylococcus epidermidis (S. epidermidis) were observed by the minimum inhibitory concentration (MIC) and disc diffusion methods. The anti‐inflammatory effects were studied in HaCaT cells based on P. acnes‐induced inflammatory mediators, including PGE2 and COX‐2, examined through enzyme‐linked immunosorbent assay (ELISA) and luciferase reporter gene assay. Thirty healthy subjects with whiteheads participated in the clinical study. Comedo counting, and the amount of sebum and porphyrin were measured before treatment and following 4 consecutive weeks of treatment with phloretin. Results Phloretin showed anti‐microbial activities against P. acnes, P. granulosum, S. epidermidis with the MIC of 0.5, 0.5 and 0.25 mg mL−1, respectively. P. acnes‐induced activation of the COX‐2 promoter was markedly attenuated by phloretin treatment. Consistent with these results, inhibition of PGE2 production was also observed. In 1‐month, placebo‐controlled trials, phloretin showed clinically and statistically significant reduction of comedo counts and sebum output level. Compared to before treatment, whiteheads, blackheads, papules, sebum output level and amount of sebum and porphyrin were significantly decreased at 4 weeks in the test group. Conclusions This study revealed that phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis. In addition, we demonstrated that phloretin attenuates COX‐2 and PGE2 expression during the P. acnes‐induced upregulation of inflammatory signalling. Clinical studies further suggested that treatment with formulations containing phloretin confers anti‐acne benefits. Based on these results, we suggest that phloretin may be introduced as a possible acne‐mitigating agent. Résumé Objectif La présente étude visait à étudier les propriétés anti‐acné de phlorétine in vitro et in vivo. Méthodes L'activité anti‐microbienne contre Propionibacterium acnes (P. acnes), Propionibacterium granulosum (P. granulosum), Staphylococcus epidermidis (S. epidermidis) a été étudiée par la method de concentration minimale inhibitrice (CMI) et par des procédés de diffusion de disque. Les effets anti‐inflammatoires ont été étudiés dans des cellules HaCaT, basés sur l'induction des médiateurs inflammatoires, y compris la PGE2 et de la COX‐2, par P. acnes et examinés par ELISA et par le dosage du gène rapporteur de luciférase. Trente sujets sains avec points blancs ont participé à l’étude clinique. Le comptage des comédonset la quantité de sébum et de la porphyrine ont été mesurés avant traitement et après quatre semaines consécutives de traitement avec la phlorétine. Résultats La phloretin a montré des activités anti‐microbiennes contre P. acnes, P. granulosum, S. epidermidis avec la CMI de 0,5, 0,5, 0,25 mg mL−1, respectivement. L'activation du promoteur de la COX‐2 induite par P. acnes a été sensiblement atténué par le traitement à la phlorétine. Conformément à ces résultats, l'inhibition de la production de PGE2 a également été observée. En un mois, les essais contrôlés par placebo, ont montré pour la phloretine une réduction cliniquement et statistiquement significative du nombre de comédons et du niveau de production de sebum. Par rapport à avant le traitement, les points blancs et noirs, les papules, le niveau de séborrhée, et la quantité de sébum et de porphyrine étaient significativement diminué à 4 semaines dans le groupe test. Conclusions La présente étude a révélé que la phlorétine inhibe la croissance de P. acnes, P. granulosum, et S. epidermidis. De plus, nous avons démontré que la phlorétine atténue l'expresssion de COX‐2 et de PGE2 au cours de l'augmentation de signalisation inflammatoire induite par P. acnes. Des études cliniques ont en outre suggéré que le traitement avec des formulations contenant phloretine confère des avantages anti‐acné. Basé sur ces résultats, nous suggérons que phloretine peut être présenté comme un agent potentiel anti‐acné. Synopsis Objective This study aimed to investigate the anti-acne properties of phloretin in vitro and in vivo. Methods Anti-microbial activity against Propionibacterium acnes (P. acnes), Propionibacterium granulosum (P. granulosum) and Staphylococcus epidermidis (S. epidermidis) were observed by the minimum inhibitory concentration (MIC) and disc diffusion methods. The anti-inflammatory effects were studied in HaCaT cells based on P. acnes-induced inflammatory mediators, including PGE2 and COX-2, examined through enzyme-linked immunosorbent assay (ELISA) and luciferase reporter gene assay. Thirty healthy subjects with whiteheads participated in the clinical study. Comedo counting, and the amount of sebum and porphyrin were measured before treatment and following 4 consecutive weeks of treatment with phloretin. Results Phloretin showed anti-microbial activities against P. acnes,P. granulosum,S. epidermidis with the MIC of 0.5, 0.5 and 0.25 mg mL-1, respectively. P. acnes-induced activation of the COX-2 promoter was markedly attenuated by phloretin treatment. Consistent with these results, inhibition of PGE2 production was also observed. In 1-month, placebo-controlled trials, phloretin showed clinically and statistically significant reduction of comedo counts and sebum output level. Compared to before treatment, whiteheads, blackheads, papules, sebum output level and amount of sebum and porphyrin were significantly decreased at 4 weeks in the test group. Conclusions This study revealed that phloretin inhibits the growth of P. acnes,P. granulosum, and S. epidermidis. In addition, we demonstrated that phloretin attenuates COX-2 and PGE2 expression during the P. acnes-induced upregulation of inflammatory signalling. Clinical studies further suggested that treatment with formulations containing phloretin confers anti-acne benefits. Based on these results, we suggest that phloretin may be introduced as a possible acne-mitigating agent. Résumé Objectif La présente étude visait à étudier les propriétés anti-acné de phlorétine in vitro et in vivo. Méthodes L'activité anti-microbienne contre Propionibacterium acnes (P. acnes), Propionibacterium granulosum (P. granulosum), Staphylococcus epidermidis (S. epidermidis) a été étudiée par la method de concentration minimale inhibitrice (CMI) et par des procédés de diffusion de disque. Les effets anti-inflammatoires ont été étudiés dans des cellules HaCaT, basés sur l'induction des médiateurs inflammatoires, y compris la PGE2 et de la COX-2, par P. acnes et examinés par ELISA et par le dosage du gène rapporteur de luciférase. Trente sujets sains avec points blancs ont participé à l'étude clinique. Le comptage des comédonset la quantité de sébum et de la porphyrine ont été mesurés avant traitement et après quatre semaines consécutives de traitement avec la phlorétine. Résultats La phloretin a montré des activités anti-microbiennes contre P. acnes, P. granulosum, S. epidermidis avec la CMI de 0,5, 0,5, 0,25 mg mL-1, respectivement. L'activation du promoteur de la COX-2 induite par P. acnes a été sensiblement atténué par le traitement à la phlorétine. Conformément à ces résultats, l'inhibition de la production de PGE2 a également été observée. En un mois, les essais contrôlés par placebo, ont montré pour la phloretine une réduction cliniquement et statistiquement significative du nombre de comédons et du niveau de production de sebum. Par rapport à avant le traitement, les points blancs et noirs, les papules, le niveau de séborrhée, et la quantité de sébum et de porphyrine étaient significativement diminué à 4 semaines dans le groupe test. Conclusions La présente étude a révélé que la phlorétine inhibe la croissance de P. acnes, P. granulosum, et S. epidermidis. De plus, nous avons démontré que la phlorétine atténue l'expresssion de COX-2 et de PGE2 au cours de l'augmentation de signalisation inflammatoire induite par P. acnes. Des études cliniques ont en outre suggéré que le traitement avec des formulations contenant phloretine confère des avantages anti-acné. Basé sur ces résultats, nous suggérons que phloretine peut être présenté comme un agent potentiel anti-acné. |
| Author | Shin, S. Kum, H. Park, D. Jung, E. Jung, K. Roh, K.-B. |
| Author_xml | – sequence: 1 givenname: H. surname: Kum fullname: Kum, H. organization: Biospectrum Life Science Institute, Sangdaewon-Dong, Gyeonggi Do, 442-13, Seongnam City, Korea – sequence: 2 givenname: K.-B. surname: Roh fullname: Roh, K.-B. organization: Biospectrum Life Science Institute, Sangdaewon-Dong, Gyeonggi Do, 442-13, Seongnam City, Korea – sequence: 3 givenname: S. surname: Shin fullname: Shin, S. organization: Biospectrum Life Science Institute, Sangdaewon-Dong, Gyeonggi Do, 442-13, Seongnam City, Korea – sequence: 4 givenname: K. surname: Jung fullname: Jung, K. organization: Biospectrum Life Science Institute, Sangdaewon-Dong, Gyeonggi Do, 442-13, Seongnam City, Korea – sequence: 5 givenname: D. surname: Park fullname: Park, D. organization: Biospectrum Life Science Institute, Sangdaewon-Dong, Gyeonggi Do, 442-13, Seongnam City, Korea – sequence: 6 givenname: E. surname: Jung fullname: Jung, E. email: bioso@biospectrum.com organization: Biospectrum Life Science Institute, Sangdaewon-Dong, Gyeonggi Do, 442-13, Seongnam City, Korea |
| BackLink | https://cir.nii.ac.jp/crid/1874242817191243392$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/26212527$$D View this record in MEDLINE/PubMed |
| BookMark | eNp90M1OVDEUB_DGYGRAF76AmUQWurjQ7_YuZQQkEFyocdm0vb2xeKcd294B3oZn8cnsfMCCRLpo0-Z3Tk7_e2AnxOAAeIvgIarryNt8iDDm5AWYIMplg2lLd8AEIoobRjnZBXs5X0MIaSvJK7CLOUaYYTEBpydLPYy6-BimsZ_qUHyjbXDTRYoLl4p3efW--DXE5IoPUx_-3i99SbHabntbxtfgZa-H7N5sz33w4_Tk--xLc_n17Hz26bKxjHHSSNRxI7qOSGINa7WUxjFjqBCtpKxeDDekpx3VtBOGYiSNta6XQosWcsPJPviw6VvH-zO6XNTcZ-uGQQcXx6yQ4FBKQlpR6fsn9DqOKdTpqmKsxVSu1butGs3cdWqR_FynO_WQUAUfN8CmmHNy_SNBUK3SVzV9tU6_2qMn1vqyzrYk7YfnKm784O7-31qdz749VBxsKoL3tf1qR1JQTLFEArUI0_p7XFmzYT4Xd_vYWKffigsimPp5daaOyQX6TOGxuiD_AEo6rq8 |
| CODEN | IJCMDW |
| CitedBy_id | crossref_primary_10_1039_D4RA03865G crossref_primary_10_1038_s41598_018_37055_y crossref_primary_10_1016_j_msec_2020_111681 crossref_primary_10_3390_ijms25115639 crossref_primary_10_3390_molecules24071319 crossref_primary_10_1002_adsc_202100201 crossref_primary_10_3390_nu14173638 crossref_primary_10_3390_molecules29174234 crossref_primary_10_1016_j_ejphar_2020_173593 crossref_primary_10_3390_biomedicines11010143 crossref_primary_10_1016_j_bmc_2023_117454 crossref_primary_10_3389_fphar_2024_1476670 crossref_primary_10_1155_2020_6267924 crossref_primary_10_1186_s12974_021_02194_z |
| Cites_doi | 10.1016/S0015-0282(01)01701-0 10.1146/annurev.nutr.21.1.381 10.5455/jmp.20130127102901 10.1093/jac/dkg449 10.1111/j.1600-0846.2009.00360.x 10.1016/S0006-291X(02)00618-6 10.1080/08927014.2010.506573 10.1161/ATVBAHA.110.207449 10.1016/S0190-9622(79)70001-6 10.1038/jid.2012.292 10.1126/science.294.5548.1871 10.4161/derm.1.3.9364 10.4103/0019-5154.48984 10.1111/j.1365-2672.2010.04677.x 10.1007/s13555-014-0063-0 10.1111/j.1742-4658.2008.06526.x 10.1002/mnfr.200800575 10.1111/j.1467-2494.2007.00378.x 10.1007/s12275-013-3015-y 10.1099/00222615-20-1-11 10.1111/j.1365-2133.1986.tb04060.x 10.1117/1.2435700 10.1111/j.1365-2133.2005.06530.x 10.1016/S0923-1811(02)00013-0 10.1016/j.clindermatol.2004.03.004 10.1371/journal.pone.0021971 10.1128/iai.63.8.3158-3165.1995 10.2165/11597880-000000000-00000 |
| ContentType | Journal Article |
| Copyright | 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie. Copyright © 2016 Society of Cosmetic Scientists and the Société Française de Cosmétologie |
| Copyright_xml | – notice: 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie – notice: 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie. – notice: Copyright © 2016 Society of Cosmetic Scientists and the Société Française de Cosmétologie |
| DBID | BSCLL RYH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QR 7U7 8FD C1K FR3 K9. P64 7X8 |
| DOI | 10.1111/ics.12263 |
| DatabaseName | Istex CiNii Complete CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Chemoreception Abstracts Toxicology Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database ProQuest Health & Medical Complete (Alumni) Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Technology Research Database Toxicology Abstracts ProQuest Health & Medical Complete (Alumni) Chemoreception Abstracts Engineering Research Database Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Technology Research Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Economics Engineering |
| EISSN | 1468-2494 |
| EndPage | 92 |
| ExternalDocumentID | 3918772251 26212527 10_1111_ics_12263 ICS12263 ark_67375_WNG_B3K1D40B_K |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea funderid: A103017 |
| GroupedDBID | --- .3N .GA .Y3 05W 0R~ 10A 1OB 1OC 29J 31~ 33P 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABDBF ABEML ABJNI ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHEFC AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BGNMA BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CAG COF CS3 CYRXZ D-6 D-7 D-E D-F DC6 DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EAD EAP EBC EBD EBS EJD EMK EMOBN ESX EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LAK LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M4Y MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NU0 O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ SV3 TEORI TUS UB1 V8K W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WRC WUP WVDHM WXI WXSBR XG1 YFH YUY ZZTAW ~IA ~WT AAHQN AAIPD AAMMB AAMNL AANHP AAYCA ACRPL ACUHS ACYXJ ADNMO AEFGJ AEYWJ AFWVQ AGQPQ AGXDD AGYGG AIDQK AIDYY ALVPJ RYH AGHNM AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QR 7U7 8FD C1K FR3 K9. P64 7X8 |
| ID | FETCH-LOGICAL-c5563-81d6b7dd383cb59a88be5bb47798458beb6b3f4d4a4d7b4218bccef87a7906b63 |
| IEDL.DBID | DR2 |
| ISSN | 0142-5463 |
| IngestDate | Thu Jul 10 19:23:13 EDT 2025 Sun Jul 13 05:12:14 EDT 2025 Wed Feb 19 01:57:41 EST 2025 Tue Jul 01 01:30:44 EDT 2025 Thu Apr 24 23:05:18 EDT 2025 Wed Aug 20 07:26:05 EDT 2025 Mon Aug 18 10:42:12 EDT 2025 Wed Oct 30 09:56:47 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | clinical study phloretin anti-inflammation anti-microbial activity |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5563-81d6b7dd383cb59a88be5bb47798458beb6b3f4d4a4d7b4218bccef87a7906b63 |
| Notes | ArticleID:ICS12263 istex:8A84DD2BC77B4F20401C28BE493BE5C79F386032 Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea - No. A103017 ark:/67375/WNG-B3K1D40B-K Hyunwoo Kum and Kyung‐Baeg Roh equally contributed to this work. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0001-5354-7286 0000-0002-5594-4645 |
| PMID | 26212527 |
| PQID | 1755924897 |
| PQPubID | 1086359 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1760883397 proquest_journals_1755924897 pubmed_primary_26212527 crossref_primary_10_1111_ics_12263 crossref_citationtrail_10_1111_ics_12263 wiley_primary_10_1111_ics_12263_ICS12263 nii_cinii_1874242817191243392 istex_primary_ark_67375_WNG_B3K1D40B_K |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | February 2016 |
| PublicationDateYYYYMMDD | 2016-02-01 |
| PublicationDate_xml | – month: 02 year: 2016 text: February 2016 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: Oxford |
| PublicationTitle | International Journal of Cosmetic Science |
| PublicationTitleAlternate | Int J Cosmet Sci |
| PublicationYear | 2016 |
| Publisher | Blackwell Publishing Ltd Wiley Wiley Subscription Services, Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Wiley – name: Wiley Subscription Services, Inc |
| References | Slayden, S.M., Moran, C. and Sams, W.M. Jr. Hyperandrogenemia in patients presenting with acne. Fertil. Steril. 75, 889-892 (2001). Zouboulis, C.C. Acne and sebaceous gland function. Clin. Dermatol. 22, 360-366 (2004). Han, B., Jung, B., Nelson, J.S. et al. Analysis of facial sebum distribution using a digital fluorescent imaging system. J. Biomed. Opt. 12, 014006 (2007). Vikram, A., Jayaprakasha, G.K., Jesudhasan, P.R. et al. Suppression of bacterial cell-cell signalling, biofilm formation and type III secretion system by citrus flavonoids. J. Appl. Microbiol. 109, 515-527 (2010). Calliste, C.A., Le Bail, J.C., Trouillas, P. et al. Chalcones: structural requirements for antioxidant, estrogenic and antiproliferative activities. Anticancer Res. 21, 3949-3956 (2001). Funk, C.D. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294, 1871-1875 (2001). Rezk, B.M., Haenen, G.R., van der Vijgh, W.J. et al. The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids. Biochem. Biophys. Res. Commun. 295, 9-13 (2002). Kang, M.S., Kim, J.H., Shin, B.A. et al. Inhibitory effect of chlorophyllin on the Propionibacterium acnes-induced chemokine expression. J. Microbiol. 51, 844-849 (2013). Jugdé, H., Nguy, D., Moller, I. et al. Isolation and characterization of a novel glycosyltransferase that converts phloretin to phlorizin, a potent antioxidant in apple. FEBS J. 275, 3804-3814 (2008). Chen, Q., Koga, T., Uchi, H. et al. Propionibacterium acnes- induced IL-8 production may be mediated by NF-KappaB activation in human monocytes. J. Dermatol. Sci. 29, 97-103 (2002). Gamble, R., Dunn, J. and Dawson, A. Topical antimicrobial treatment of acne vulgaris: an evidence-based review. Am. J. Clin. Dermatol. 13, 141-152 (2012). Kappachery, S., Paul, D., Yoon, J. et al. Vanillin, a potential agent to prevent biofouling of reverse osmosis membrane. Biofouling 26, 667-672 (2010). Shu, M., Kuo, S., Wang, Y. et al. Porphyrin metabolisms in human skin commensal Propionibacterium acnes bacteria: potential application to monitor human radiation risk. Curr. Med. Chem. 20, 562-568 (2013). Susan, V. and Bershad, M.D. Modern age of acne therapy. Mt. Sinai J. Med. 68, 279-286 (2001). Taylor, E.J., Yu, Y., Champer, J. and Kim, J. Resveratrol demonstrates antimicrobial effects against Propionibacterium acnes in vitro. Dermatol. Ther. (Heidelb.) 4, 249-257 (2014). CTFA Safety Testing Guideline, pp. 20005. The Cosmetic, Toiletry and Fragrance Association, Inc., Washington, DC (1981). Leeming, J.P., Holland, K.T. and Cunliffe, W.J. The pathological and ecological significance of microorganisms colonizing acne vulgaris comedones. J. Med. Microbiol. 20, 11-16 (1985). Yang, C., Yang, Z., Zhang, M. et al. Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. PLoS One 6, e21971 (2011). Saint-Leger, D., Bague, A., Cohen, E. et al. Possible role for squalene in the pathogenesis of acne. In vitro study of squalene oxidation. Br. J. Dermatol. 114, 535-542 (1986). Abulnaja, K.O. Oxidant/antioxidant status in obese adolescent females with acne vulgaris. Indian J. Dermatol. 54, 36-40 (2009). Ricciotti, E. and FitzGerald, G.A. Prostaglandins and inflammation. Arterioscler. Thromb. Vasc. Biol. 31, 986-1000 (2011). Ahmed, S.S., Haidar, H.A. and Ahemed, R.A. Oxidative stress in acne vulgaris: an important therapeutic target. J. Mol. Pathophysiol. 2, 27-31 (2013). Yoon, J.Y., Kwon, H.H., Min, S.U. et al. Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes. J. Invest. Dermatol. 133, 429-440 (2013). Schaller, M., Loewenstein, M., Borelli, C. et al. Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with Propionibacterium acnes and coproporphyrin III. Br. J. Dermatol. 153, 66-71 (2005). Koo, H., Hayacibara, M.F., Schobel, B.D. et al. Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. J. Antimicrob. Chemother. 52, 782-789 (2003). Jung, M., Triebel, S., Anke, T. et al. Influence of apple polyphenols on inflammatory gene expression. Mol. Nutr. Food Res. 53, 1263-1280 (2009). Frosch, P.J. and Kligman, A.M. The soap chamber test. A new method for assessing the irritancy of soaps. J. Am. Acad. Dermatol. 1, 35-41 (1979). Youn, S.W., Kim, J.H., Lee, J.E. et al. The facial red fluorescence of ultraviolet photography: is this color due to Propionibacterium acnes or the unknown content of secreted sebum? Skin Res. Technol. 15, 230-236 (2009). Yang, C.S., Landau, J.M., Huang, M.T. et al. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr. 21, 381-406 (2001). Layton, A. The use of isotretinoin in acne. Dermato-endocrinology 1, 162-169 (2009). Basal, E., Jain, A. and Kaushal, G.P. Antibody response to crude cell lysate of Propionibacterium acnes and induction of pro inflammatory cytokines in patients with acne and normal healthy subjects. J. Microbiol. 42, 117-125 (2004). Pavicic, T., Wollenweber, U., Farwick, M. et al. Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris. Int. J. Cosmet. Sci. 29, 181-190 (2007). Vowels, B.R., Yang, S. and Leyden, J.J. Introduction of pro-inflammatory cytokines by a soluble factor of Propionibacerium acnes: implications for chronic inflammatory acne. Infect. Immun. 63, 3158-3165 (1995). 2004; 22 2004; 42 1986; 114 2010; 109 2013; 2 2005; 153 2002; 295 2013; 20 2011; 31 2012; 13 1985; 20 2001; 68 2011; 6 2003; 52 2007; 12 2001; 21 1995; 63 2007; 29 2001; 294 2010; 26 2014; 4 2002; 29 2009; 54 2009; 53 2013; 51 2013; 133 1979; 1 1981 2009; 1 2008; 275 2009; 15 2001; 75 Susan V. (e_1_2_6_21_1) 2001; 68 Ahmed S.S. (e_1_2_6_28_1) 2013; 2 e_1_2_6_32_1 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_30_1 (e_1_2_6_13_1) 1981 Shu M. (e_1_2_6_16_1) 2013; 20 Vowels B.R. (e_1_2_6_9_1) 1995; 63 e_1_2_6_19_1 e_1_2_6_14_1 Basal E. (e_1_2_6_11_1) 2004; 42 e_1_2_6_34_1 e_1_2_6_12_1 e_1_2_6_33_1 Calliste C.A. (e_1_2_6_4_1) 2001; 21 e_1_2_6_17_1 e_1_2_6_18_1 e_1_2_6_15_1 e_1_2_6_20_1 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_7_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_22_1 e_1_2_6_29_1 e_1_2_6_27_1 e_1_2_6_26_1 |
| References_xml | – reference: Yang, C.S., Landau, J.M., Huang, M.T. et al. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr. 21, 381-406 (2001). – reference: Gamble, R., Dunn, J. and Dawson, A. Topical antimicrobial treatment of acne vulgaris: an evidence-based review. Am. J. Clin. Dermatol. 13, 141-152 (2012). – reference: Leeming, J.P., Holland, K.T. and Cunliffe, W.J. The pathological and ecological significance of microorganisms colonizing acne vulgaris comedones. J. Med. Microbiol. 20, 11-16 (1985). – reference: Rezk, B.M., Haenen, G.R., van der Vijgh, W.J. et al. The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids. Biochem. Biophys. Res. Commun. 295, 9-13 (2002). – reference: Shu, M., Kuo, S., Wang, Y. et al. Porphyrin metabolisms in human skin commensal Propionibacterium acnes bacteria: potential application to monitor human radiation risk. Curr. Med. Chem. 20, 562-568 (2013). – reference: Chen, Q., Koga, T., Uchi, H. et al. Propionibacterium acnes- induced IL-8 production may be mediated by NF-KappaB activation in human monocytes. J. Dermatol. Sci. 29, 97-103 (2002). – reference: Funk, C.D. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294, 1871-1875 (2001). – reference: Yoon, J.Y., Kwon, H.H., Min, S.U. et al. Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes. J. Invest. Dermatol. 133, 429-440 (2013). – reference: Ricciotti, E. and FitzGerald, G.A. Prostaglandins and inflammation. Arterioscler. Thromb. Vasc. Biol. 31, 986-1000 (2011). – reference: Youn, S.W., Kim, J.H., Lee, J.E. et al. The facial red fluorescence of ultraviolet photography: is this color due to Propionibacterium acnes or the unknown content of secreted sebum? Skin Res. Technol. 15, 230-236 (2009). – reference: Abulnaja, K.O. Oxidant/antioxidant status in obese adolescent females with acne vulgaris. Indian J. Dermatol. 54, 36-40 (2009). – reference: Saint-Leger, D., Bague, A., Cohen, E. et al. Possible role for squalene in the pathogenesis of acne. In vitro study of squalene oxidation. Br. J. Dermatol. 114, 535-542 (1986). – reference: Yang, C., Yang, Z., Zhang, M. et al. Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. PLoS One 6, e21971 (2011). – reference: Kappachery, S., Paul, D., Yoon, J. et al. Vanillin, a potential agent to prevent biofouling of reverse osmosis membrane. Biofouling 26, 667-672 (2010). – reference: Zouboulis, C.C. Acne and sebaceous gland function. Clin. Dermatol. 22, 360-366 (2004). – reference: Vowels, B.R., Yang, S. and Leyden, J.J. Introduction of pro-inflammatory cytokines by a soluble factor of Propionibacerium acnes: implications for chronic inflammatory acne. Infect. Immun. 63, 3158-3165 (1995). – reference: Vikram, A., Jayaprakasha, G.K., Jesudhasan, P.R. et al. Suppression of bacterial cell-cell signalling, biofilm formation and type III secretion system by citrus flavonoids. J. Appl. Microbiol. 109, 515-527 (2010). – reference: CTFA Safety Testing Guideline, pp. 20005. The Cosmetic, Toiletry and Fragrance Association, Inc., Washington, DC (1981). – reference: Calliste, C.A., Le Bail, J.C., Trouillas, P. et al. Chalcones: structural requirements for antioxidant, estrogenic and antiproliferative activities. Anticancer Res. 21, 3949-3956 (2001). – reference: Frosch, P.J. and Kligman, A.M. The soap chamber test. A new method for assessing the irritancy of soaps. J. Am. Acad. Dermatol. 1, 35-41 (1979). – reference: Pavicic, T., Wollenweber, U., Farwick, M. et al. Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris. Int. J. Cosmet. Sci. 29, 181-190 (2007). – reference: Jugdé, H., Nguy, D., Moller, I. et al. Isolation and characterization of a novel glycosyltransferase that converts phloretin to phlorizin, a potent antioxidant in apple. FEBS J. 275, 3804-3814 (2008). – reference: Basal, E., Jain, A. and Kaushal, G.P. Antibody response to crude cell lysate of Propionibacterium acnes and induction of pro inflammatory cytokines in patients with acne and normal healthy subjects. J. Microbiol. 42, 117-125 (2004). – reference: Ahmed, S.S., Haidar, H.A. and Ahemed, R.A. Oxidative stress in acne vulgaris: an important therapeutic target. J. Mol. Pathophysiol. 2, 27-31 (2013). – reference: Layton, A. The use of isotretinoin in acne. Dermato-endocrinology 1, 162-169 (2009). – reference: Han, B., Jung, B., Nelson, J.S. et al. Analysis of facial sebum distribution using a digital fluorescent imaging system. J. Biomed. Opt. 12, 014006 (2007). – reference: Taylor, E.J., Yu, Y., Champer, J. and Kim, J. Resveratrol demonstrates antimicrobial effects against Propionibacterium acnes in vitro. Dermatol. Ther. (Heidelb.) 4, 249-257 (2014). – reference: Kang, M.S., Kim, J.H., Shin, B.A. et al. Inhibitory effect of chlorophyllin on the Propionibacterium acnes-induced chemokine expression. J. Microbiol. 51, 844-849 (2013). – reference: Jung, M., Triebel, S., Anke, T. et al. Influence of apple polyphenols on inflammatory gene expression. Mol. Nutr. Food Res. 53, 1263-1280 (2009). – reference: Slayden, S.M., Moran, C. and Sams, W.M. Jr. Hyperandrogenemia in patients presenting with acne. Fertil. Steril. 75, 889-892 (2001). – reference: Susan, V. and Bershad, M.D. Modern age of acne therapy. Mt. Sinai J. Med. 68, 279-286 (2001). – reference: Koo, H., Hayacibara, M.F., Schobel, B.D. et al. Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. J. Antimicrob. Chemother. 52, 782-789 (2003). – reference: Schaller, M., Loewenstein, M., Borelli, C. et al. Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with Propionibacterium acnes and coproporphyrin III. Br. J. Dermatol. 153, 66-71 (2005). – volume: 31 start-page: 986 year: 2011 end-page: 1000 article-title: Prostaglandins and inflammation publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 42 start-page: 117 year: 2004 end-page: 125 article-title: Antibody response to crude cell lysate of and induction of pro inflammatory cytokines in patients with acne and normal healthy subjects publication-title: J. Microbiol. – volume: 53 start-page: 1263 year: 2009 end-page: 1280 article-title: Influence of apple polyphenols on inflammatory gene expression publication-title: Mol. Nutr. Food Res. – volume: 63 start-page: 3158 year: 1995 end-page: 3165 article-title: Introduction of pro‐inflammatory cytokines by a soluble factor of : implications for chronic inflammatory acne publication-title: Infect. Immun. – start-page: 20005 year: 1981 – volume: 68 start-page: 279 year: 2001 end-page: 286 article-title: Modern age of acne therapy publication-title: Mt. Sinai J. Med. – volume: 20 start-page: 562 year: 2013 end-page: 568 article-title: Porphyrin metabolisms in human skin commensal bacteria: potential application to monitor human radiation risk publication-title: Curr. Med. Chem. – volume: 2 start-page: 27 year: 2013 end-page: 31 article-title: Oxidative stress in acne vulgaris: an important therapeutic target publication-title: J. Mol. Pathophysiol. – volume: 109 start-page: 515 year: 2010 end-page: 527 article-title: Suppression of bacterial cell–cell signalling, biofilm formation and type III secretion system by citrus flavonoids publication-title: J. Appl. Microbiol. – volume: 13 start-page: 141 year: 2012 end-page: 152 article-title: Topical antimicrobial treatment of acne vulgaris: an evidence‐based review publication-title: Am. J. Clin. Dermatol. – volume: 6 start-page: e21971 year: 2011 article-title: Hydrogen sulfide protects against chemical hypoxia‐induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF‐ B/COX‐2 pathway publication-title: PLoS One – volume: 21 start-page: 3949 year: 2001 end-page: 3956 article-title: Chalcones: structural requirements for antioxidant, estrogenic and antiproliferative activities publication-title: Anticancer Res. – volume: 52 start-page: 782 year: 2003 end-page: 789 article-title: Inhibition of biofilm accumulation and polysaccharide production by apigenin and ‐farnesol publication-title: J. Antimicrob. Chemother. – volume: 294 start-page: 1871 year: 2001 end-page: 1875 article-title: Prostaglandins and leukotrienes: advances in eicosanoid biology publication-title: Science – volume: 133 start-page: 429 year: 2013 end-page: 440 article-title: Epigallocatechin‐3‐gallate improves acne in humans by modulating intracellular molecular targets and inhibiting publication-title: J. Invest. Dermatol. – volume: 295 start-page: 9 year: 2002 end-page: 13 article-title: The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids publication-title: Biochem. Biophys. Res. Commun. – volume: 54 start-page: 36 year: 2009 end-page: 40 article-title: Oxidant/antioxidant status in obese adolescent females with acne vulgaris publication-title: Indian J. Dermatol. – volume: 51 start-page: 844 year: 2013 end-page: 849 article-title: Inhibitory effect of chlorophyllin on the ‐induced chemokine expression publication-title: J. Microbiol. – volume: 1 start-page: 35 year: 1979 end-page: 41 article-title: The soap chamber test. A new method for assessing the irritancy of soaps publication-title: J. Am. Acad. Dermatol. – volume: 20 start-page: 11 year: 1985 end-page: 16 article-title: The pathological and ecological significance of microorganisms colonizing acne vulgaris comedones publication-title: J. Med. Microbiol. – volume: 114 start-page: 535 year: 1986 end-page: 542 article-title: Possible role for squalene in the pathogenesis of acne. In vitro study of squalene oxidation publication-title: Br. J. Dermatol. – volume: 21 start-page: 381 year: 2001 end-page: 406 article-title: Inhibition of carcinogenesis by dietary polyphenolic compounds publication-title: Annu. Rev. Nutr. – volume: 153 start-page: 66 year: 2005 end-page: 71 article-title: Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with and coproporphyrin III publication-title: Br. J. Dermatol. – volume: 275 start-page: 3804 year: 2008 end-page: 3814 article-title: Isolation and characterization of a novel glycosyltransferase that converts phloretin to phlorizin, a potent antioxidant in apple publication-title: FEBS J. – volume: 15 start-page: 230 year: 2009 end-page: 236 article-title: The facial red fluorescence of ultraviolet photography: is this color due to or the unknown content of secreted sebum? publication-title: Skin Res. Technol. – volume: 1 start-page: 162 year: 2009 end-page: 169 article-title: The use of isotretinoin in acne publication-title: Dermato‐endocrinology – volume: 22 start-page: 360 year: 2004 end-page: 366 article-title: Acne and sebaceous gland function publication-title: Clin. Dermatol. – volume: 29 start-page: 97 year: 2002 end-page: 103 article-title: ‐ induced IL‐8 production may be mediated by NF‐KappaB activation in human monocytes publication-title: J. Dermatol. Sci. – volume: 29 start-page: 181 year: 2007 end-page: 190 article-title: Anti‐microbial and ‐inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris publication-title: Int. J. Cosmet. Sci. – volume: 75 start-page: 889 year: 2001 end-page: 892 article-title: Hyperandrogenemia in patients presenting with acne publication-title: Fertil. Steril. – volume: 12 start-page: 014006 year: 2007 article-title: Analysis of facial sebum distribution using a digital fluorescent imaging system publication-title: J. Biomed. Opt. – volume: 4 start-page: 249 year: 2014 end-page: 257 article-title: Resveratrol demonstrates antimicrobial effects against in vitro publication-title: Dermatol. Ther. (Heidelb.) – volume: 26 start-page: 667 year: 2010 end-page: 672 article-title: Vanillin, a potential agent to prevent biofouling of reverse osmosis membrane publication-title: Biofouling – ident: e_1_2_6_18_1 doi: 10.1016/S0015-0282(01)01701-0 – ident: e_1_2_6_3_1 doi: 10.1146/annurev.nutr.21.1.381 – volume: 2 start-page: 27 year: 2013 ident: e_1_2_6_28_1 article-title: Oxidative stress in acne vulgaris: an important therapeutic target publication-title: J. Mol. Pathophysiol. doi: 10.5455/jmp.20130127102901 – volume: 21 start-page: 3949 year: 2001 ident: e_1_2_6_4_1 article-title: Chalcones: structural requirements for antioxidant, estrogenic and antiproliferative activities publication-title: Anticancer Res. – ident: e_1_2_6_5_1 doi: 10.1093/jac/dkg449 – ident: e_1_2_6_32_1 doi: 10.1111/j.1600-0846.2009.00360.x – ident: e_1_2_6_2_1 doi: 10.1016/S0006-291X(02)00618-6 – ident: e_1_2_6_6_1 doi: 10.1080/08927014.2010.506573 – ident: e_1_2_6_15_1 doi: 10.1161/ATVBAHA.110.207449 – ident: e_1_2_6_12_1 doi: 10.1016/S0190-9622(79)70001-6 – volume: 20 start-page: 562 year: 2013 ident: e_1_2_6_16_1 article-title: Porphyrin metabolisms in human skin commensal Propionibacterium acnes bacteria: potential application to monitor human radiation risk publication-title: Curr. Med. Chem. – ident: e_1_2_6_24_1 doi: 10.1038/jid.2012.292 – ident: e_1_2_6_14_1 doi: 10.1126/science.294.5548.1871 – ident: e_1_2_6_22_1 doi: 10.4161/derm.1.3.9364 – volume: 42 start-page: 117 year: 2004 ident: e_1_2_6_11_1 article-title: Antibody response to crude cell lysate of Propionibacterium acnes and induction of pro inflammatory cytokines in patients with acne and normal healthy subjects publication-title: J. Microbiol. – ident: e_1_2_6_19_1 doi: 10.4103/0019-5154.48984 – ident: e_1_2_6_7_1 doi: 10.1111/j.1365-2672.2010.04677.x – start-page: 20005 volume-title: CTFA Safety Testing Guideline year: 1981 ident: e_1_2_6_13_1 – ident: e_1_2_6_23_1 doi: 10.1007/s13555-014-0063-0 – ident: e_1_2_6_27_1 doi: 10.1111/j.1742-4658.2008.06526.x – ident: e_1_2_6_8_1 doi: 10.1002/mnfr.200800575 – ident: e_1_2_6_25_1 doi: 10.1111/j.1467-2494.2007.00378.x – ident: e_1_2_6_26_1 doi: 10.1007/s12275-013-3015-y – ident: e_1_2_6_17_1 doi: 10.1099/00222615-20-1-11 – ident: e_1_2_6_34_1 doi: 10.1111/j.1365-2133.1986.tb04060.x – volume: 68 start-page: 279 year: 2001 ident: e_1_2_6_21_1 article-title: Modern age of acne therapy publication-title: Mt. Sinai J. Med. – ident: e_1_2_6_31_1 doi: 10.1117/1.2435700 – ident: e_1_2_6_33_1 doi: 10.1111/j.1365-2133.2005.06530.x – ident: e_1_2_6_10_1 doi: 10.1016/S0923-1811(02)00013-0 – ident: e_1_2_6_30_1 doi: 10.1016/j.clindermatol.2004.03.004 – ident: e_1_2_6_29_1 doi: 10.1371/journal.pone.0021971 – volume: 63 start-page: 3158 year: 1995 ident: e_1_2_6_9_1 article-title: Introduction of pro‐inflammatory cytokines by a soluble factor of Propionibacerium acnes: implications for chronic inflammatory acne publication-title: Infect. Immun. doi: 10.1128/iai.63.8.3158-3165.1995 – ident: e_1_2_6_20_1 doi: 10.2165/11597880-000000000-00000 |
| SSID | ssj0004983 ssib006548215 |
| Score | 2.1702805 |
| Snippet | Synopsis
Objective
This study aimed to investigate the anti‐acne properties of phloretin in vitro and in vivo.
Methods
Anti‐microbial activity against... This study aimed to investigate the anti-acne properties of phloretin in vitro and in vivo. Anti-microbial activity against Propionibacterium acnes (P. acnes),... Synopsis Objective This study aimed to investigate the anti-acne properties of phloretin in vitro and in vivo. Methods Anti-microbial activity against... OBJECTIVEThis study aimed to investigate the anti-acne properties of phloretin in vitro and in vivo.METHODSAnti-microbial activity against Propionibacterium... |
| SourceID | proquest pubmed crossref wiley nii istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 85 |
| SubjectTerms | Acne Acne Vulgaris Acne Vulgaris - drug therapy Acne Vulgaris - microbiology anti-inflammation anti-microbial activity clinical study Cyclooxygenase 2 Cyclooxygenase 2 - metabolism Dinoprost Dinoprost - metabolism Humans In Vitro Techniques Microbial activity Microbial Sensitivity Tests Phloretin Phloretin - therapeutic use |
| Title | Evaluation of anti-acne properties of phloretin in vitro and in vivo |
| URI | https://api.istex.fr/ark:/67375/WNG-B3K1D40B-K/fulltext.pdf https://cir.nii.ac.jp/crid/1874242817191243392 https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fics.12263 https://www.ncbi.nlm.nih.gov/pubmed/26212527 https://www.proquest.com/docview/1755924897 https://www.proquest.com/docview/1760883397 |
| Volume | 38 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3ZbtUwEB1VRWJ5YLlQuNCigBDqS65uYseLeKIbF6r2AajoA1Jkx46IWiVXd6kQT3wCn8C38Cl8CTPZaFGREC9RLE8ULzP2GXt8DPDMxE5qn7NQSK9D7lCNjVNZmOk8ShSLEl-fkDs4FJMj_uY4OV6BF91ZmIYfol9wI8uox2sycGPn54y8yOajCMEDMX1GTBBv_s7b39RRXDcUnBEnrn_BWlYhiuLpv7wwF12hZv2MU0xZFJfBzYvotZ5-9m7Bx67gTdTJyWi5sKPsyx-cjv9Zs9tws4WlwctGj-7Aii8HcK07tTwfwI1zxIUDuHrQbsnfhcluzxceVHmAHVX8_PrNZKUPprTQPyPGVsqZfjqtj0yWQVH--H5WLGYVSrs2dVbdg6O93ffbk7C9niHMiFUsRKQrrHQOfdzMJtooZX1iLZdSK55gwgrLcu644U5ajljCZpnPlTRSj4UVbA1Wy6r0DyDQVFsuVR4Lx12UK_SRmbJaGsc4DsdD2Ow6Ks1a7nK6QuM07XwYbIq0brMhPO1Fpw1hx2VCz-ve7iXM7IQi3GSSfjh8lW6x_WiHj7fS_SFsoDrgP-lJ1xciolGRRCc35gyh5RDWO0VJW-PHX0h002KutBzCkz4bzZb2YkzpqyXJiDHd80wy9xsF6wsTC8QTSYw5m7Wa_L0e6evtd_XLw38XfQTXEfS1kefrsLqYLf0GAquFfVxb0C81lhp7 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JbtRAEC2FRCJwYBk2QwIGIZSLR2N3uxeJC9mYMJk5QKLkgiz3YmElskeTmQhx4hP4BL6FT-FLqPZGgoKEuFhudVnupar7VS-vAF6mkeHSZiRg3MqAGlTj1AgdaJmFsSBhbKsbcuMJGx7Sd8fx8RK8bu_C1PwQ3YKbs4xqvHYG7hakL1h5rs_6IaIHcg1WKAIN53ptv_9NHkVlTcIZUsf2z0jDK-TO8XSfXpqNVlzDfsZJpsjzqwDnZfxaTUC7t-FjW_T63MlJfzFXff3lD1bH_63bHbjVIFP_Ta1Kd2HJFj1YbS8un_Xg5gXuwh5cHze78vdguNNRhvtl5mNf5T-_fkt1Yf2pW-ufOdJWlzP9dFrdmiz8vPjx_Tyfz0qUNk3qvLwPh7s7B1vDoInQEGhHLBYg2GWKG4NurlaxTIVQNlaKci4FjTGhmCIZNTSlhiuKcEJpbTPBUy4HTDHyAJaLsrCPwJeutpSLLGKGmjAT6CYToSRPDaE4Inuw0fZUohv6chdF4zRp3RhsiqRqMw9edKLTmrPjKqFXVXd3EunsxB1y43FyNHmbbJJRuE0Hm8nIg3XUB_yne7oIhghqRMjRz40oQXTpwVqrKUlj__gLjp5aRIXkHjzvstFy3XZMWthy4WTYwIV6djIPaw3rChMxhBRxhDkblZ78vR7J3taH6uXxv4s-g9XhwXg_2d-bjJ7ADcSAzUH0NViezxZ2HXHWXD2tzOkX35Memg |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9RAFD7UFqo-VF1bTW01ikhfsjSZyVzwyV7WrWsXUYt9EELmEgwtybLdLeKTP8Gf4G_xp_hLPJObrVQQX0KGOcnczpn5zly-AXiaRoZLm5GAcSsDalCNUyN0oGUWxoKEsa1OyB2O2fCIvjqOjxfgeXsWpuaH6CbcnGVU_bUz8InJLhh5rs_6IYIHcg2WKEMk4RDR29_cUVTWHJwhdWT_jDS0Qm4bT_fppcFoydXrZxxjijy_Cm9ehq_V-DO4BR_bnNfbTk7685nq6y9_kDr-Z9Fuw0qDS_0XtSLdgQVb9OB6e2z5rAc3LzAX9mD5sFmTvwvD_Y4w3C8zH1sq__n1W6oL60_cTP_UUba6mMmn0-rMZOHnxY_v5_lsWqK0aULn5SocDfbf7w6D5n6GQDtasQChLlPcGHRytYplKoSysVKUcylojAHFFMmooSk1XFEEE0prmwmecrnNFCNrsFiUhb0PvnSlpVxkETPUhJlAJ5kIJXlqCMX-2IOttqES3ZCXuzs0TpPWicGqSKo68-BJJzqpGTuuEnpWtXYnkU5P3BY3Hicfxi-THTIK9-j2TjLyYBPVAdN0T3d_IUIaEXL0ciNKEFt6sNEqStJYPybB0U-LqJDcg8ddNNqtW4xJC1vOnQzqrMBfoMy9WsG6zEQMAUUcYcxWpSZ_L0dysPuueln_d9FHsPxmb5C8PhiPHsANBIDNLvQNWJxN53YTQdZMPayM6RdmSh1J |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluation+of+anti-acne+properties+of+phloretin+in+vitro+and+in+vivo&rft.jtitle=International+journal+of+cosmetic+science&rft.au=Kum%2C+H&rft.au=Roh%2C+K-B&rft.au=Shin%2C+S&rft.au=Jung%2C+K&rft.date=2016-02-01&rft.pub=Wiley+Subscription+Services%2C+Inc&rft.issn=0142-5463&rft.eissn=1468-2494&rft.volume=38&rft.issue=1&rft.spage=85&rft_id=info:doi/10.1111%2Fics.12263&rft.externalDBID=NO_FULL_TEXT&rft.externalDocID=3918772251 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0142-5463&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0142-5463&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0142-5463&client=summon |