Inhibition of neutral amino acid transport across the human blood-brain barrier by phenylalanine

• Published in: Journal of neurochemistry Vol. 64; no. 3; p. 1252
• Main Authors: Shulkin, B L, Betz, A L, Koeppe, R A, Agranoff, B W
• Format: Journal Article
• Language: English
• Published: England 01.03.1995
• Subjects: Adult; Amino Acids - metabolism; Amino Acids, Cyclic; Biological Transport - drug effects; Blood-Brain Barrier - drug effects; Cyclohexanecarboxylic Acids - metabolism; Humans; Kinetics; Male; Phenylalanine - blood; Phenylalanine - pharmacology; Tomography, Emission-Computed

The delivery of large neutral amino acids (LNAAs) to brain across the blood-brain barrier (BBB) is mediated by the L-type neutral amino acid transporter present in the membranes of the brain capillary endothelial cell. In experimental animals, the L-system transporter is saturated under normal condi...