The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases

• Published in: Human mutation Vol. 29; no. 3; pp. 351 - 360
• Main Authors: Szeverenyi, Ildiko, Cassidy, Andrew J., Chung, Cheuk Wang, Lee, Bernett T.K., Common, John E.A., Ogg, Stephen C., Chen, Huijia, Sim, Shu Yin, Goh, Walter L.P., Ng, Kee Woei, Simpson, John A., Chee, Li Lian, Eng, Goi Hui, Li, Bin, Lunny, Declan P., Chuon, Danny, Venkatesh, Aparna, Khoo, Kian Hoe, McLean, W.H. Irwin, Lim, Yun Ping, Lane, E. Birgitte
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2008
• Subjects: Algorithms; Amino Acid Sequence; Base Sequence; Chromosome Mapping; Databases, Genetic; desmin; DNA, Complementary - genetics; epidermolysis bullosa; GFAP; Humans; intermediate filament; Intermediate Filament Proteins - genetics; keratin; lamin; laminopathy; Molecular Sequence Data; Multigene Family; Mutation; neurofilament; Polymorphism, Genetic; Sequence Alignment - statistics & numerical data; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid

We describe a revised and expanded database on human intermediate filament proteins, a major component of the eukaryotic cytoskeleton. The family of 70 intermediate filament genes (including those encoding keratins, desmins, and lamins) is now known to be associated with a wide range of diverse dise...