Paracaspase MALT1 regulates glioma cell survival by controlling endo‐lysosome homeostasis

• Published in: The EMBO journal Vol. 39; no. 1; pp. e102030 - n/a
• Main Authors: Jacobs, Kathryn A, André‐Grégoire, Gwennan, Maghe, Clément, Thys, An, Li, Ying, Harford‐Wright, Elizabeth, Trillet, Kilian, Douanne, Tiphaine, Alves Nicolau, Carolina, Frénel, Jean‐Sébastien, Bidère, Nicolas, Gavard, Julie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.01.2020; Springer Nature B.V; EMBO Press; John Wiley and Sons Inc
• Subjects: Aged; Animals; Antigens; Apoptosis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Brain cancer; Brain tumors; Cancer; Catalytic activity; Cell activation; Cell death; Cell Proliferation; Cell survival; Deactivation; Depletion; EMBO03; EMBO07; EMBO20; Endosomes - metabolism; Endosomes - pathology; Female; Gene expression; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Glioma - genetics; Glioma - metabolism; Glioma - pathology; Glioma cells; Homeostasis; Humans; Inactivation; Life Sciences; Lymphocyte Activation; Lymphoid tissue; Lymphoma; lysosome; Lysosomes; Lysosomes - metabolism; Lysosomes - pathology; Male; MALT1; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; mTOR; Mucosa; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein - genetics; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein - metabolism; Mucosal-associated lymphoid tissue; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Paracaspases; Pharmacology; Protease; Proteinase; Proteolysis; Ribonucleic acid; RNA; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Signal Transduction; Survival; Therapeutic applications; TOR protein; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Tumor Cells, Cultured; Tumors; Xenograft Model Antitumor Assays; protease; mTOR; glioma; lysosome; MALT1; protease Subject Categories Cancer; Autophagy & Cell Death; Membranes & Traf- ficking
• ISSN: 0261-4189; 1460-2075; 1460-2075
• DOI: 10.15252/embj.2019102030

Glioblastoma is one of the most lethal forms of adult cancer with a median survival of around 15 months. A potential treatment strategy involves targeting glioblastoma stem‐like cells (GSC), which constitute a cell autonomous reservoir of aberrant cells able to initiate, maintain, and repopulate the...