Millisecond dynamics of an unlabeled amino acid transporter

• Published in: Nature communications Vol. 11; no. 1; p. 5016
• Main Authors: Matin, Tina R., Heath, George R., Huysmans, Gerard H. M., Boudker, Olga, Scheuring, Simon
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.10.2020; Nature Portfolio
• Subjects: 14/3; 631/1647/2204/1262; 631/378/2587; 631/535/1262; 631/57/2265; Humanities and Social Sciences; multidisciplinary; Science; Science (multidisciplinary)

Excitatory amino acid transporters (EAATs) are important in many physiological processes and crucial for the removal of excitatory amino acids from the synaptic cleft. Here, we develop and apply high-speed atomic force microscopy line-scanning (HS-AFM-LS) combined with automated state assignment and...